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RIFINs are adhesins...
RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
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- Goel, Suchi (author)
- Karolinska Institutet
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Palmkvist, Mia (author)
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- Moll, Kirsten (author)
- Karolinska Institutet
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show more...
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Joannin, Nicolas (author)
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- Lara, Patricia (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Akhouri, Reetesh R. (author)
- Karolinska Institutet
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- Moradi, Nasim (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Öjemalm, Karin (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Westman, Mattias (author)
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Angeletti, Davide (author)
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- Kjellin, Hanna (author)
- Karolinska Institutet
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- Lehtio, Janne (author)
- Karolinska Institutet
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Blixt, Ola (author)
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Ideström, Lars (author)
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Gahmberg, Carl G. (author)
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- Storry, Jill (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Hult, Annika (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Olsson, Martin L (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- von Heijne, Gunnar (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Nilsson, IngMarie (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Wahlgren, Mats (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2015-03-09
- 2015
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 21:4, s. 314-317
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Goel, Suchi
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Palmkvist, Mia
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Moll, Kirsten
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Joannin, Nicolas
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Lara, Patricia
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Akhouri, Reetesh ...
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show more...
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Moradi, Nasim
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Öjemalm, Karin
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Westman, Mattias
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Angeletti, David ...
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Kjellin, Hanna
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Lehtio, Janne
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Blixt, Ola
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Ideström, Lars
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Gahmberg, Carl G ...
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Storry, Jill
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Hult, Annika
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Olsson, Martin L
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von Heijne, Gunn ...
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Nilsson, IngMari ...
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Wahlgren, Mats
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Nature Medicine
- By the university
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Stockholm University
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Lund University
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Karolinska Institutet