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Vinylic MIDA Borona...
Vinylic MIDA Boronates : New Building Blocks for the Synthesis of Aza-Heterocycles
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- Llona-Minguez, Sabin (author)
- Karolinska Institutet
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- Desroses, Matthieu (author)
- Karolinska Institutet
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Ghassemian, Artin (author)
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Jacques, Sylvain A. (author)
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- Eriksson, Lars (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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Isacksson, Rebecka (author)
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- Koolmeister, Tobias (author)
- Karolinska Institutet
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- Stenmark, Pål (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Scobie, Martin (author)
- Karolinska Institutet
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- Helleday, Thomas (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2015-03-25
- 2015
- English.
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In: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 21:20, s. 7394-7398
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A two-step synthesis of structurally diverse pyrrole-containing bicyclic systems is reported. ortho-Nitro-haloarenes coupled with vinylic N-methyliminodiacetic acid (MIDA) boronates generate ortho-vinyl-nitroarenes, which undergo a metal-free nitrene insertion, resulting in a new pyrrole ring. This novel synthetic approach has a wide substrate tolerance and it is applicable in the preparation of more complex drug-like molecules. Interestingly, an ortho-nitro-allylarene derivative furnished a cyclic beta-aminophosphonate motif.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- aminophosphonate
- boronate
- cyclization
- heterocycles
- MIDA
- nitrene
Publication and Content Type
- ref (subject category)
- art (subject category)
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Llona-Minguez, S ...
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Desroses, Matthi ...
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Ghassemian, Arti ...
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Jacques, Sylvain ...
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Eriksson, Lars
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Isacksson, Rebec ...
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show more...
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Koolmeister, Tob ...
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Stenmark, Pål
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Scobie, Martin
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Helleday, Thomas
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Chemistry - A Eu ...
- By the university
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Stockholm University
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Karolinska Institutet