Search: onr:"swepub:oai:DiVA.org:su-119154" >
Circular RNAs in th...
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
-
Rybak-Wolf, Agnieszka (author)
-
Stottmeister, Christin (author)
-
Glazar, Petar (author)
-
show more...
-
Jens, Marvin (author)
-
Pino, Natalia (author)
-
Giusti, Sebastian (author)
-
Hanan, Mor (author)
-
- Behm, Mikaela (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
Bartok, Osnat (author)
-
Ashwal-Fluss, Reut (author)
-
Herzog, Margareta (author)
-
Schreyer, Luisa (author)
-
Papavasileiou, Panagiotis (author)
-
Ivanov, Andranik (author)
-
- Öhman, Marie (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
Refojo, Damian (author)
-
Kadener, Sebastian (author)
-
Rajewsky, Nikolaus (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
-
In: Molecular Cell. - : Elsevier BV. - 1097-2765 .- 1097-4164. ; 58:5, s. 870-885
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Molecular Biology
- molekylärbiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rybak-Wolf, Agni ...
-
Stottmeister, Ch ...
-
Glazar, Petar
-
Jens, Marvin
-
Pino, Natalia
-
Giusti, Sebastia ...
-
show more...
-
Hanan, Mor
-
Behm, Mikaela
-
Bartok, Osnat
-
Ashwal-Fluss, Re ...
-
Herzog, Margaret ...
-
Schreyer, Luisa
-
Papavasileiou, P ...
-
Ivanov, Andranik
-
Öhman, Marie
-
Refojo, Damian
-
Kadener, Sebasti ...
-
Rajewsky, Nikola ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
- Articles in the publication
-
Molecular Cell
- By the university
-
Stockholm University