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Molecular architecture of the active mitochondrial protein gate
- Shiota, Takuya (author)
- Imai, Kenichiro (author)
- Qiu, Jian (author)
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- Hewitt, Victoria L. (author)
- Tan, Khershing (author)
- Shen, Hsin-Hui (author)
- Sakiyama, Noriyuki (author)
- Fukasawa, Yoshinori (author)
- Kamiya, Megumi (author)
- Tomii, Kentaro (author)
- Horton, Paul (author)
- Wiedemann, Nils (author)
- Pfanner, Nikolaus (author)
- Lithgow, Trevor (author)
- Endo, Toshiya (author)
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- (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2015
- 2015
- English.
- In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 349:6255, s. 1544-1548
- Journal article (peer-reviewed)
Abstract
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- Mitochondria fulfill central functions in cellular energetics, metabolism, and signaling. The outer membrane translocator complex (the TOM complex) imports most mitochondrial proteins, but its architecture is unknown. Using a cross-linking approach, we mapped the active translocator down to single amino acid residues, revealing different transport paths for preproteins through the Tom40 channel. An N-terminal segment of Tom40 passes from the cytosol through the channel to recruit chaperones fromthe intermembrane space that guide the transfer of hydrophobic preproteins. The translocator contains three Tom40 beta-barrel channels sandwiched between a central alpha-helical Tom22 receptor cluster and external regulatory Tom proteins. The preprotein-translocating trimeric complex exchanges with a dimeric isoform to assemble new TOM complexes. Dynamic coupling of alpha-helical receptors, beta-barrel channels, and chaperones generates a versatile machinery that transports about 1000 different proteins.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
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- Kamiya, Megumi
- Elofsson, Arne
- Tomii, Kentaro
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- Lithgow, Trevor
- Endo, Toshiya
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