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Common variants in ...
Common variants in the ARC gene are not associated withcognitive abilities
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Myrum, Craig (author)
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Giddaluru, Sudheer (author)
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Jacobsen, Kaya (author)
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Espeseth, Thomas (author)
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Nyberg, Lars (author)
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Lundervold, Astri J. (author)
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Haavik, Jan (author)
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- Nilsson, Lars-Göran (author)
- Umeå universitet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden,Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institutet, Stockholm, Sweden
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Reinvang, Ivar (author)
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Steen, Vidar M. (author)
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Johansson, Stefan (author)
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Wibrand, Karin (author)
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Le Hellard, Stephanie (author)
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Bramham, Clive R. (author)
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(creator_code:org_t)
- 2015-09-03
- 2015
- English.
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In: Brain and Behavior. - : Wiley. - 2162-3279 .- 2162-3279. ; 5:10
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Abstract
Subject headings
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- Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic plasticity, we hypothesized that genetic variations in ARC may contribute to interindividual variability in human cognitive abilities or to attention-deficit hyperactivity disorder (ADHD) susceptibility, where cognitive impairment often accompanies the disorder. Methods: We tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS). In addition, the Swedish Betula sample of 1800 healthy subjects who underwent similar cognitive testing was also tested for association with 19 tag SNPs. Results: No ARC variants show association at the study-wide level, but several markers show a trend toward association with human cognitive functions. We also tested for association between ARCSNPs and ADHD in a Norwegian sample of cases and controls, but found no significant associations. Conclusion: This study suggests that common genetic variants located in ARC do not account for variance in human cognitive abilities, though small effects cannot be ruled out.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Activity-regulated cytoskeleton-associated protein
- cognition
- genetics
- memory
- single-nucleotide polymorphism
- synaptic plasticity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Myrum, Craig
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Giddaluru, Sudhe ...
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Jacobsen, Kaya
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Espeseth, Thomas
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Nyberg, Lars
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Lundervold, Astr ...
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show more...
-
Haavik, Jan
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Nilsson, Lars-Gö ...
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Reinvang, Ivar
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Steen, Vidar M.
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Johansson, Stefa ...
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Wibrand, Karin
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Le Hellard, Step ...
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Bramham, Clive R ...
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show less...
- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Brain and Behavi ...
- By the university
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Stockholm University
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Umeå University
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Karolinska Institutet