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Membrane insertion ...
Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6 (MRP6)
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Cuviello, Flavia (author)
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- Tellgren-Roth, Åsa (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Lara, Patricia (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Ruud Selin, Frida (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Monné, Magnus (author)
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Bisaccia, Faustino (author)
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- Nilsson, IngMarie (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Ostuni, Angela (author)
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(creator_code:org_t)
- 2015-11-03
- 2015
- English.
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In: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 589:24, s. 3921-3928
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The function of the ATP-binding cassette transporter MRP6 is unknown but mutations in its gene cause pseudoxanthoma elasticum. We have investigated the membrane topology of the N-terminal transmembrane domain TMD0 of MRP6 and the membrane integration and orientation propensities of its transmembrane segments (TMs) by glycosylation mapping. Results demonstrate that TMD0 has five TMs, an Nout-Cin topology and that the less hydrophobic TMs have strong preference for their orientation in the membrane that affects the neighboring TMs. Two disease-causing mutations changing the number of positive charges in the loops of TMD0 did not affect the membrane insertion efficiencies of the adjacent TMs.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- ATP-binding cassette transporter
- Multidrug-resistance associated protein 6
- ABCC6
- Transmembrane domain
- Pseudoxanthoma elasticum
- Membrane protein insertion
Publication and Content Type
- ref (subject category)
- art (subject category)
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