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- Mazari, Aslam M. A.Stockholms universitet,Institutionen för neurokemi (author)
Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- Elsevier BV,2016
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-126346
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-126346URI
- https://doi.org/10.1016/j.bbrep.2015.12.003DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) and the related 2,4-dinitrotoluene (DNT) aretoxic environmental pollutants. The biotransformation and detoxication of these persistent compoundsin higher organisms are of great significance from a health perspective as well as for the biotechnological challenge of bioremediation of contaminated soil. We demonstrate that different human glutathionetransferases (GSTs) and GSTs from the fruit fly Drosophila melanogaster are catalysts of the biotransformationof TNT and DNT. The human GSTs had significant but modest catalytic activities with both DNT and TNT. However, D. melanogaster GSTE6 and GSTE7 displayed outstanding high activities withboth substrates.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- NATURVETENSKAP Kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences hsv//eng
- Glutathione conjugation
- 2
- 4
- 6-trinitrotoluene detoxication
- 2
- 4-dinitrotoluene detoxication
- Drosophila GSTs
- Human GSTs
- neurokemi med molekylär neurobiologi
- Neurochemistry with Molecular Neurobiology
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- Mannervik, BengtStockholms universitet,Institutionen för neurokemi(Swepub:su)bmann (author)
- Stockholms universitetInstitutionen för neurokemi (creator_code:org_t)
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- In:Biochemistry and Biophysics Reports: Elsevier BV5, s. 141-1452405-5808
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