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- Merlin, Jon (author)
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2015-08-27
- Wiley,2016
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-126383
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-126383URI
- https://doi.org/10.1002/mnfr.201500251DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- There are two types of adipose tissue with distinct functions-white adipose tissue stores chemical energy as triglycerides, whereas brown adipose tissue consumes energy and releases heat (thermogenesis) in response to sympathetic nerve activity. In humans, treatments that promote greater brown adipose tissue deposition and/or activity would be highly beneficial in regimes aimed at reducing obesity. Adult humans have restricted populations of prototypical brown adipocytes in the neck and chest areas, but recent advances have established that adipocytes with similar properties, termed brite adipocytes, can be recruited in subcutaneous depots thought to be primarily white adipose tissue. These brite adipocytes express the protein machinery required for thermogenesis, but to assess brite adipocytes as viable therapeutic targets we need to understand how to promote conversion of white adipocytes to brite adipocytes and ways to increase optimal energy consumption and thermogenesis in these brite adipocytes. This can be accomplished by pharmacological and nutritional therapies to differing degrees, as reviewed in detail here.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
- Brown adipose tissue
- Thermogenesis
- UCP1
- White adipose tissue
Added entries (persons, corporate bodies, meetings, titles ...)
- Evans, Bronwyn A. (author)
- Dehvari, NodiStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)node4175 (author)
- Sato, Masaaki (author)
- Bengtsson, ToreStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)tbeng (author)
- Hutchinson, Dana S. (author)
- Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)
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- In:Molecular Nutrition & Food Research: Wiley60:1, s. 18-421613-41251613-4133
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