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Diabetes, glycaemia...
Diabetes, glycaemia, and cognitiona secondary analysis of the Finnish Diabetes Prevention Study
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Lehtisalo, Jenni (author)
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Lindström, Jaana (author)
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- Ngandu, Tiia (author)
- Karolinska Institutet
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- Kivipelto, Miia (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),National Institute for Health and Welfare, Finland; University of Eastern Finland, Sweden
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Ahtiluoto, Satu (author)
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Ilanne-Parikka, Pirjo (author)
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Keinanen-Kiukaanniemi, Sirkka (author)
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Eriksson, Johan G. (author)
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Uusitupa, Matti (author)
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Tuomilehto, Jaakko (author)
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Luchsinger, Jose A. (author)
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(creator_code:org_t)
- 2015-08-18
- 2016
- English.
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In: Diabetes/Metabolism Research Reviews. - : Wiley. - 1520-7552 .- 1520-7560. ; 32:1, s. 102-110
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https://helda.helsin...
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https://urn.kb.se/re...
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Abstract
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- Background: Type 2 diabetes is linked with cognitive dysfunction and dementia in epidemiological studies, but these observations are limited by lack of data on the exact timing of diabetes onset. We investigated diabetes, dysglycaemia, and cognition in the Finnish Diabetes Prevention Study, in which the timing and duration of diabetes are well documented.Methods: The Finnish Diabetes Prevention Study comprised middle-aged, overweight participants with impaired glucose tolerance but no diabetes at baseline (n=522), randomized to lifestyle intervention or a control group. After an intervention period (mean duration 4years) and follow-up (additional 9years), cognitive assessment with the CERAD test battery and Trail Making Test A (TMT) was executed twice within a 2-year interval. Of the 364 (70%) participants with cognitive assessments, 171 (47%) had developed diabetes.Results: Cognitive function did not differ between those who developed diabetes and those who did not. Lower mean 2-h glucose at an oral glucose tolerance test (OGTT) and HbA(1C) during the intervention period predicted better performance in the TMT (p=0.012 and 0.024, respectively). Those without diabetes or with short duration of diabetes improved in CERAD total score between the two assessments (p=0.001) whereas those with long duration of diabetes did not (p=0.844).Conclusions: Better glycemic control among persons with baseline impaired glucose tolerance predicted better cognitive performance 9years later in this secondary analysis of the Finnish Diabetes Prevention Study population. In addition, learning effects in cognitive testing were not evident in people with long diabetes duration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- type 2 diabetes
- dysglycaemia
- cognition
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lehtisalo, Jenni
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Lindström, Jaana
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Ngandu, Tiia
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Kivipelto, Miia
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Ahtiluoto, Satu
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Ilanne-Parikka, ...
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show more...
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Keinanen-Kiukaan ...
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Eriksson, Johan ...
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Uusitupa, Matti
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Tuomilehto, Jaak ...
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Luchsinger, Jose ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Diabetes/Metabol ...
- By the university
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Stockholm University
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Karolinska Institutet