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TESS : an R package for efficiently simulating phylogenetic trees and performing Bayesian inference of lineage diversification rates

Höhna, Sebastian (author)
Stockholms universitet,Matematiska institutionen,University of California, USA
May, Michael R. (author)
Moore, Brian R. (author)
 (creator_code:org_t)
2015-11-04
2016
English.
In: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811. ; 32:5, s. 789-791
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Many fundamental questions in evolutionary biology entail estimating rates of lineage diversification (speciation-extinction) that are modeled using birth-death branching processes. We leverage recent advances in branching-process theory to develop a flexible Bayesian framework for specifying diversification models-where rates are constant, vary continuously, or change episodically through time-and implement numerical methods to estimate parameters of these models from molecular phylogenies, even when species sampling is incomplete. We enable both statistical inference and efficient simulation under these models. We also provide robust methods for comparing the relative and absolute fit of competing branching-process models to a given tree, thereby providing rigorous tests of biological hypotheses regarding patterns and processes of lineage diversification.

Subject headings

NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Miljöbioteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Environmental Biotechnology (hsv//eng)
NATURVETENSKAP  -- Data- och informationsvetenskap (hsv//swe)
NATURAL SCIENCES  -- Computer and Information Sciences (hsv//eng)
NATURVETENSKAP  -- Matematik (hsv//swe)
NATURAL SCIENCES  -- Mathematics (hsv//eng)

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By the author/editor
Höhna, Sebastian
May, Michael R.
Moore, Brian R.
About the subject
NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
ENGINEERING AND TECHNOLOGY
ENGINEERING AND ...
and Environmental Bi ...
NATURAL SCIENCES
NATURAL SCIENCES
and Computer and Inf ...
NATURAL SCIENCES
NATURAL SCIENCES
and Mathematics
Articles in the publication
Bioinformatics
By the university
Stockholm University

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