Search: onr:"swepub:oai:DiVA.org:su-134045" >
HFpEF and HFrEF Dis...
-
Ljung Faxén, UlrikaKarolinska Institutet
(author)
HFpEF and HFrEF Display Different Phenotypes as Assessed by IGF-1 and IGFBP-1
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
Elsevier BV,2017
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-134045
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-134045URI
-
https://doi.org/10.1016/j.cardfail.2016.06.008DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:135632733URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BackgroundAnabolic drive is impaired in heart failure with reduced ejection fraction (HFrEF) but insufficiently studied in heart failure with preserved ejection fraction (HFpEF). Insulin-like growth factor 1 (IGF-1) mediates growth hormone effects and IGF binding protein 1 (IGFBP-1) regulates IGF-1 activity. We tested the hypothesis that HFpEF and HFrEF are similar with regard to IGF-1 and IGFBP-1.Methods and ResultsIn patients with HFpEF (n = 79), HFrEF (n = 85), and controls (n = 136), we analyzed serum IGF-1 and IGFBP-1 concentrations, correlations, and associations with outcome. Age-standardized scores of IGF-1 were higher in HFpEF, median arbitrary units (interquartile range); 1.21 (0.57–1.96) vs HFrEF, 0.09 (-1.40–1.62), and controls, 0.22 (-0.47-0.96), P overall <.001. IGFBP-1 was increased in HFpEF, 48 (28–79), and HFrEF, 65 (29–101), vs controls, 27(14–35) µg/L, P overall <.001. These patterns persisted after adjusting for metabolic and HF severity confounders. IGF-1 was associated with outcomes in HFrEF, hazard ratio per natural logarithmic increase in IGF-1 SD score 0.51 (95% confidence interval 0.32–0.82, P = .005), but not significantly in HFpEF. IGFBP-1 was not associated with outcomes in either HFpEF nor HFrEF.ConclusionHFpEF and HFrEF phenotypes were similar with regard to increased IGFBP-1 concentrations but differed regarding IGF-1 levels and prognostic role. HFrEF and HFpEF may display different impairment in anabolic drive.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Hage, CamillaKarolinska Institutet
(author)
-
Benson, LinaKarolinska Institutet
(author)
-
Zabarovskaja, Stanislava
(author)
-
Andreasson, AnnaKarolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Karolinska institutet, Sweden(Swepub:su)anan6088
(author)
-
Donal, Erwan
(author)
-
Daubert, Jean-Claude
(author)
-
Linde, CeciliaKarolinska Institutet
(author)
-
Brismar, KerstinKarolinska Institutet
(author)
-
Lund, Lars H.Karolinska Institutet
(author)
-
Karolinska InstitutetStressforskningsinstitutet
(creator_code:org_t)
Related titles
-
In:Journal of Cardiac Failure: Elsevier BV23:4, s. 293-3031071-91641532-8414
Internet link
Find in a library
To the university's database
- By the author/editor
-
Ljung Faxén, Ulr ...
-
Hage, Camilla
-
Benson, Lina
-
Zabarovskaja, St ...
-
Andreasson, Anna
-
Donal, Erwan
-
show more...
-
Daubert, Jean-Cl ...
-
Linde, Cecilia
-
Brismar, Kerstin
-
Lund, Lars H.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Journal of Cardi ...
- By the university
-
Stockholm University
-
Karolinska Institutet