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Characterization of...
Characterization of Mn(II) ion binding to the amyloid-beta peptide in Alzheimer's disease
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- Wallin, Cecilia (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
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- Kulkarni, Yashraj S. (author)
- Uppsala universitet,Struktur- och molekylärbiologi
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- Abelein, Axel (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Karolinska Institutet, Sweden,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc NVS, H1,Novum Pl 5, S-14157 Stockholm, Sweden.
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- Jarvet, Jüri (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,The National Institute of Chemical Physics and Biophysics, Estonia,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;NICPB, Akad Tee 23, EE-12618 Tallinn, Estonia.
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- Liao, Qinghua (author)
- Forschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany.
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- Strodel, Birgit (author)
- Forschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany.;Univ Dusseldorf, Inst Theoret & Computat Chem, Univ Str 1, D-40225 Dusseldorf, Germany.
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- Olsson, Lisa (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
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- Luo, Jinghui (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,University of Oxford, UK,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Univ Oxford, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England.
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- Abrahams, Jan Pieter (author)
- Univ Basel, Biozentrum, Klingelbergstr 70, CH-4056 Basel, Switzerland.;Paul Scherrer Inst, Dept Biol & Chem, Lab Biomol Res, OFLC 102, CH-5232 Villigen, Switzerland.
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- Sholts, Sabrina B. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,National Museum of Natural History, USA,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.;Smithsonian Inst, Natl Museum Nat Hist, Dept Anthropol, 10th & Constitut Ave NW, Washington, DC 20013 USA.
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- Roos, Per M. (author)
- Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.;Capio St Goran Hosp, Dept Clin Physiol, St Goransplan 1, S-11219 Stockholm, Sweden.
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- Kamerlin, Shina C. L. (author)
- Uppsala universitet,Struktur- och molekylärbiologi
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- Gräslund, Astrid (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
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- Wärmländer, Sebastian K. T. S. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden.
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Journal of Trace Elements in Medicine and Biology. - : Elsevier BV. - 0946-672X .- 1878-3252. ; 38, s. 183-193
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Abstract
Subject headings
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- Growing evidence links neurodegenerative diseases to metal exposure. Aberrant metal ion concentrations have been noted in Alzheimer's disease (AD) brains, yet the role of metals in AD pathogenesis remains unresolved. A major factor in AD pathogenesis is considered to be aggregation of and amyloid formation by amyloid-beta (A beta) peptides. Previous studies have shown that A beta displays specific binding to Cu(II) and Zn(II) ions, and such binding has been shown to modulate A beta aggregation. Here, we use nuclear magnetic resonance (NMR) spectroscopy to show that Mn(II) ions also bind to the N-terminal part of the A beta(1-40) peptide, with a weak binding affinity in the milli- to micromolar range. Circular dichroism (CD) spectroscopy, solid state atomic force microscopy (AFM), fluorescence spectroscopy, and molecular modeling suggest that the weak binding of Mn(II) to A beta may not have a large effect on the peptide's aggregation into amyloid fibrils. However, identification of an additional metal ion displaying A beta binding reveals more complex AD metal chemistry than has been previously considered in the literature.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Manganese
- Neurodegeneration
- Metal-protein binding
- Spectroscopy
- Molecular dynamics
- Biophysics
- biofysik
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wallin, Cecilia
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Kulkarni, Yashra ...
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Abelein, Axel
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Jarvet, Jüri
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Liao, Qinghua
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Strodel, Birgit
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show more...
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Olsson, Lisa
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Luo, Jinghui
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Abrahams, Jan Pi ...
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Sholts, Sabrina ...
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Roos, Per M.
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Kamerlin, Shina ...
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Gräslund, Astrid
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Wärmländer, Seba ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Journal of Trace ...
- By the university
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Stockholm University
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Uppsala University