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BDNF Responses in H...
BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness : Associations with Working Memory Function
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- Håkansson, Krister, 1952- (author)
- Karolinska Institutet,Linnéuniversitetet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Institutionen för psykologi (PSY),Karolinska Institutet ; Stockholm University
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- Ledreux, Aurelie (author)
- Karolinska Institutet ; Medical University of South Carolina, USA
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- Daffner, Kirk (author)
- Harvard Medical School, USA
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- Terjestam, Yvonne (author)
- Linnéuniversitetet,Institutionen för psykologi (PSY)
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- Bergman, Patrick (author)
- Linnéuniversitetet,Institutionen för idrottsvetenskap (ID)
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- Carlsson, Roger (author)
- Linnéuniversitetet,Institutionen för psykologi (PSY)
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- Kivipelto, Miia (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet
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- Winblad, Bengt (author)
- Karolinska Institutet
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- Granholm, Ann-Charlotte (author)
- Karolinska Institutet
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Mohammed, Abdul Kadir H. (author)
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(creator_code:org_t)
- IOS Press, 2017
- 2017
- English.
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In: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 55:2, s. 645-657
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Abstract
Subject headings
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- Brain-derived neurotrophic factor (BDNF) has a central role in brain plasticity by mediating changes in cortical thickness and synaptic density in response to physical activity and environmental enrichment. Previous studies suggest that physical exercise can augment BDNF levels, both in serum and the brain, but no other study has examined how different types of activities compare with physical exercise in their ability to affect BDNF levels. By using a balanced cross over experimental design, we exposed nineteen healthy older adults to 35-minute sessions of physical exercise, cognitive training, and mindfulness practice, and compared the resulting changes in mature BDNF levels between the three activities. We show that a single bout of physical exercise has significantly larger impact on serum BDNF levels than either cognitive training or mindfulness practice in the same persons. This is the first study on immediate BDNF effects of physical activity in older healthy humans and also the first study to demonstrate an association between serum BDNF responsivity to acute physical exercise and working memory function. We conclude that the BDNF increase we found after physical exercise more probably has a peripheral than a central origin, but that the association between post-intervention BDNF levels and cognitive function could have implications for BDNF responsivity in serum as a potential marker of cognitive health.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Aging
- brain-derived neurotrophic factor
- cognitive function
- cognitive training
- crossover design
- exercise
- geriatrics
- intervention study
- mindfulness
- neuroplasticity
- Psychology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Håkansson, Krist ...
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Ledreux, Aurelie
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Daffner, Kirk
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Terjestam, Yvonn ...
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Bergman, Patrick
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Carlsson, Roger
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show more...
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Kivipelto, Miia
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Winblad, Bengt
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Granholm, Ann-Ch ...
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Mohammed, Abdul ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Stockholm University
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Linnaeus University
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Karolinska Institutet