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CYTOTOXIC EFFECTS O...
CYTOTOXIC EFFECTS OF THE RED SEA SOFT CORAL SARCOPHYTON TROCHELIOPHORUM
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- El-Seedi, Hesham R. (author)
- Uppsala universitet,Avdelningen för farmakognosi,Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia.;Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
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- Gomaa, Mohamed (author)
- Univ Jeddah, Fac Sci & Arts, Dept Biol, Khulais, Saudi Arabia.
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- Salem, Mousa Maali (author)
- Univ Jeddah, Fac Sci & Arts, Dept Biol, Khulais, Saudi Arabia.
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- Benchoula, Khaled (author)
- Int Islamic Univ Malaysia, Fac Pharm, Dept Pharmaceut Chem, Kuantan 25200, Pahang, Malaysia.
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- Keshk, Hager M. (author)
- Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
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- Yosri, Nermeen (author)
- Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
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- Ayesh, Ahmed (author)
- Univ Jeddah, Fac Sci & Arts, Dept Biol, Khulais, Saudi Arabia.,Karolinska Univ Hosp, Dept Expt Hematol, SE-14186 Stockholm, Sweden.;Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden.
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- Asker, Ahmed M. (author)
- Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
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- Soliman, Kawther (author)
- Univ Jeddah, Fac Sci & Arts, Dept Biol, Khulais, Saudi Arabia.
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- Hamza, Zeinab (author)
- Natl Res Ctr, Food Toxins & Contaminants Dept, Marine Toxins Lab, Cairo, Egypt.
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- Mansour, Hager M. (author)
- Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.
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- Elkhateeb, Ahmed (author)
- Natl Res Ctr, Phytochem & Plant Systemat Dept, Pharmaceut & Drug Ind Res Div, Cairo, Egypt.
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- Khalifa, Shaden A. M. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Karolinska University Hospital, Sweden
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(creator_code:org_t)
- POLSKIE TOWARZYSTWO FARMACEUTYCZNE, 2016
- 2016
- English.
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In: Acta Poloniae Pharmaceutica. - : POLSKIE TOWARZYSTWO FARMACEUTYCZNE. - 0001-6837. ; 73:6, s. 1587-1592
- Related links:
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http://www.ptfarm.pl...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The present study describes the in vitro cytotoxic effects of soft coral (Sarcophyton trocheliophorum). Soft corals of genus Sarcophyton were reported to contain compounds that arc active against brine shrimp and promote paclitaxel cytotoxicity in the human colon cancer Caco-2 cell line. The a-hexane extract of the soft coral Sarcophyton trocheliophorum induced significant dose-dependent toxicity (LC50 96.7 ppm) compared with ethyl acetate (LC50 120 ppm). We reported the most active cytotoxic level to be correspondence to LC50 values of 20.2, 59.2 ppm and 18.9 and 26 ppm. Accordingly, bio-assay guided fractionation was conducted to identify the bioactive compounds. Arachidonic acid. eicosapentaenoic acid and docosahexaenoic acid were characterized based on GC-MS analyses. Our results demonstrate the value of marine products as a natural source of medicinally interesting cytotoxic compounds.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- cytotoxic activity
- GC-MS
- Sarcophyton trocheliophorum
- soft coral
- unsaturated fatty acid
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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El-Seedi, Hesham ...
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Gomaa, Mohamed
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Salem, Mousa Maa ...
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Benchoula, Khale ...
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Keshk, Hager M.
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Yosri, Nermeen
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Ayesh, Ahmed
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Asker, Ahmed M.
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Soliman, Kawther
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Hamza, Zeinab
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Mansour, Hager M ...
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Elkhateeb, Ahmed
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Khalifa, Shaden ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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Acta Poloniae Ph ...
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Stockholm University
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Uppsala University