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Multi-pathway human exposure assessment of phthalate esters and DINCH

Giovanoulis, Georgios (author)
Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
Bui, Tuong Thuy (author)
Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
Xu, Fuchao (author)
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Covaci, Adrian (author)
Palm Cousins, Anna (author)
Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
Magnér, Jörgen (author)
Cousins, Ian T. (author)
Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
de Wit, Cynthia A. (author)
Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
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 (creator_code:org_t)
English.
Related links:
https://urn.kb.se/re...
  • Other publication (other academic/artistic)
Abstract Subject headings
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  • Phthalate esters are substances mainly used as plasticizers in various applications. Some have been restricted and phased out due to their adverse health effects and ubiquitous presence, leading to the introduction of alternative plasticizers, such as DINCH. Using a comprehensive dataset from a Norwegian study population, human exposure to DMP, DEP, DnBP, DiBP, BBzP, DEHP, DINP, DIDP, DPHP and DINCH was assessed by measuring their presence in external exposure media, allowing an estimation of the total intake, as well as the relative importance of different uptake pathways. Intake via different uptake routes, in particular inhalation, dermal absorption, and oral uptake was estimated and total intake based on all uptake pathways was compared to the back-calculated intake from biomonitoring data. Hand wipe results were used to determine dermal uptake and compared to other exposure sources such as air, dust and personal care products. Results showed that the calculated total intakes were similar, but slightly higher than those based on biomonitoring methods by 1.1 to 2.8 times (median), indicating a good understanding of important uptake pathways. The relative importance of different uptake pathways was comparable to other studies, where inhalation was important for lower molecular weight phthalates, and negligible for the higher molecular weight phthalates and DINCH. Dietary intake was the predominant exposure route for all analyzed substances. The dermal uptake assessed by hand wipes was much lower (median up to 2000 times) than the sum of dermal uptake via air, dust and personal care products and unlikely represents an integrative dermal exposure. Dermal uptake is not a well-studied exposure pathway and several research gaps (e.g. absorption fractions) remain. Based on calculated intakes, the exposure risk for the Norwegian participants to the phthalates and DINCH was lower than health based limit values. Nevertheless, exposure to alternative plasticizers, such as DPHP and DINCH, is expected to increase in the future and continuous monitoring is required.

Subject headings

NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

Keyword

Phthalate esters
DPHP
DINCH
plasticizers
exposure assessment
Applied Environmental Science
tillämpad miljövetenskap

Publication and Content Type

vet (subject category)
ovr (subject category)

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