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- Athanasiadou, MariaStockholms universitet,Institutionen för miljökemi (author)
Polybrominated diphenyl ethers (PBDEs) and bioaccumulative hydroxylated PBDE metabolites in young humans from Managua, Nicaragua.
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- Environmental Health Perspectives,2008
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-14229
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-14229URI
- https://lup.lub.lu.se/record/1193622URI
- https://doi.org/10.1289/ehp.10713DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- OBJECTIVE: Our aim was to investigate exposure to polybrominated diphenyl ethers (PBDEs) in a young urban population in a developing country, with focus on potentially highly exposed children working informally as scrap scavengers at a large municipal waste disposal site. We also set out to investigate whether hydroxylated metabolites, which not hitherto have been found retained in humans, could be detected. METHODS: We assessed PBDEs in pooled serum samples obtained in 2002 from children 11-15 years of age, working and sometimes also living at the municipal waste disposal site in Managua, and in nonworking urban children. The influence of fish consumption was evaluated in the children and in groups of women 15-44 years of age who differed markedly in their fish consumption. Hydroxylated PBDEs were assessed as their methoxylated derivates. The chemical analyses were performed by gas chromatography/mass spectrometry, using authentic reference substances. RESULTS: The children living and working at the waste disposal site showed very high levels of medium brominated diphenyl ethers. The levels observed in the referent children were comparable to contemporary observations in the United States. The exposure pattern was consistent with dust being the dominating source. The children with the highest PBDE levels also had the highest levels of hydroxylated metabolites. CONCLUSIONS: Unexpectedly, very high levels of PBDEs were found in children from an urban area in a developing country. Also, for the first time, hydroxylated PBDE metabolites were found to bioaccumulate in human serum.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
- Adolescent
- Adult
- Animals
- Child
- Child; Preschool
- Diet
- Environmental Exposure
- Environmental Pollutants/*blood
- Female
- Fishes
- Humans
- Inhalation Exposure
- Male
- Nicaragua
- Occupational Exposure
- Phenyl Ethers/*blood
- Polybrominated Biphenyls/*blood
- Refuse Disposal
- Urban Health
- Water Pollutants; Chemical/blood
- inhalation
- exposure
- human
- fish consumption
- children
- brominated flame retardants
- BFRs
- metabolism
- OH-PBDEs
- waste disposal site
Added entries (persons, corporate bodies, meetings, titles ...)
- Cuadra, StevenLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-scu (author)
- Marsh, GöranStockholms universitet,Institutionen för miljökemi (author)
- Bergman, ÅkeStockholms universitet,Institutionen för miljökemi (author)
- Jakobsson, KristinaLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-kja (author)
- Stockholms universitetInstitutionen för miljökemi (creator_code:org_t)
Related titles
- In:Environ Health Perspect: Environmental Health Perspectives116:3, s. 400-80091-67651552-9924
Internet link
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18335110&dopt=Citation
- http://dx.doi.org/10.1289/ehp.10713FULLTEXT
- https://doi.org/10.1289/ehp.10713
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-14229
- https://lup.lub.lu.se/record/1193622
- https://doi.org/10.1289/ehp.10713
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