onr:"swepub:oai:DiVA.org:su-142559"
Search: onr:"swepub:oai:DiVA.org:su-142559" > Improved health-spa...
- 1 of 1
- Previous record
- Next record
- To hitlist
Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1
-
- Shabalina, Irina G. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
- Vyssokikh, Mikhail Yu. (author)
-
- Gibanova, Natalia (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
- show more...
- Bakeeva, Lora E. (author)
- Vays, Valeria B. (author)
- Pustovidko, Antonina V. (author)
- Skulachev, Maxim V. (author)
- Skulachev, Vladimir P. (author)
- show less...
- (creator_code:org_t)
- 2017-02-15
- 2017
- English.
- In: Aging. - : Impact Journals, LLC. - 1945-4589. ; 9:2, s. 315-339
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of approximate to 100 days with the mitochondria-targeted antioxidant SkQ1 showed a delayed appearance of traits of aging such as kyphosis, alopecia, lowering of body temperature, body weight loss, as well as ameliorated heart, kidney and liver pathologies. These effects of SkQ1 are suggested to be related to an alleviation of the effects of an enhanced reactive oxygen species (ROS) level in mtDNA mutator mice: the increased mitochondrial ROS released due to mitochondrial mutations probably interact with polyunsaturated fatty acids in cardiolipin, releasing malondialdehyde and 4-hydroxynonenal that form protein adducts and thus diminishes mitochondrial functions. SkQ1 counteracts this as it scavenges mitochondrial ROS. As the results, the normal mitochondrial ultrastructure is preserved in liver and heart; the phosphorylation capacity of skeletal muscle mitochondria as well as the thermogenic capacity of brown adipose tissue is also improved. The SkQ1-treated mice live significantly longer (335 versus 290 days). These data may be relevant in relation to treatment of mitochondrial diseases particularly and the process of aging in general.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- reactive oxygen species
- oxidative stress
- mitochondria
- cardiolipin
- thermogenesis
- brown adipose tissue
- longevity
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Shabalina, Irina ...
- Vyssokikh, Mikha ...
- Gibanova, Natali ...
- Csikasz, Robert ...
- Edgar, Daniel
- Hallden-Waldemar ...
- show more...
- Rozhdestvenskaya ...
- Bakeeva, Lora E.
- Vays, Valeria B.
- Pustovidko, Anto ...
- Skulachev, Maxim ...
- Cannon, Barbara
- Skulachev, Vladi ...
- Nedergaard, Jan
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- Articles in the publication
- Aging
- By the university
- Stockholm University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
