Search: onr:"swepub:oai:DiVA.org:su-143136" >
Glucose uptake in b...
-
Olsen, Jessica M.Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
(author)
Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation
- Article/chapterEnglish2014
Publisher, publication year, extent ...
-
2014-11-10
-
Rockefeller University Press,2014
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-143136
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-143136URI
-
https://doi.org/10.1083/jcb.201403080DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Brown adipose tissue is the primary site for thermogenesis and can consume, in addition to free fatty acids, a very high amount of glucose from the blood, which can both acutely and chronically affect glucose homeostasis. Here, we show that mechanistic target of rapamycin (mTOR) complex 2 has a novel role in β3-adrenoceptor-stimulated glucose uptake in brown adipose tissue. We show that β3-adrenoceptors stimulate glucose uptake in brown adipose tissue via a signaling pathway that is comprised of two different parts: one part dependent on cAMP-mediated increases in GLUT1 transcription and de novo synthesis of GLUT1 and another part dependent on mTOR complex 2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane, leading to increased glucose uptake. Both parts are essential for β3-adrenoceptor-stimulated glucose uptake. Importantly, the effect of β3-adrenoceptor on mTOR complex 2 is independent of the classical insulin-phosphoinositide 3-kinase-Akt pathway, highlighting a novel mechanism of mTOR complex 2 activation.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Sato, MasaakiStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Monash Institute of Pharmaceutical Sciences, Australia
(author)
-
Dallner, Olof S.Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,The Rockefeller University, USA
(author)
-
Sandström, Anna L.Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)ansa2665
(author)
-
Pisani, Didier F.
(author)
-
Jean-Claude, Chambard
(author)
-
Amri, Ez-Zoubir
(author)
-
Hutchinson, Dana S.
(author)
-
Bengtsson, ToreStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)tbeng
(author)
-
Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
Related titles
-
In:Journal of Cell Biology: Rockefeller University Press207:30021-95251540-8140
Internet link
Find in a library
To the university's database