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On-line extraction ...
On-line extraction and determination of residual sulfathiazole in pharmaceutical wastewater with molecularly imprinted polymers in a packed cartridge coupled with high-performance liquid chromatography
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Zazouli, Mohammad Ali (author)
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Akbari-adergani, Behrouz (author)
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Javanbakht, Mehran (author)
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- Moein, Mohammad Mahdi (author)
- Karolinska Institutet,Stockholms universitet,Institutionen för analytisk kemi
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Analytical Methods. - : Royal Society of Chemistry (RSC). - 1759-9660 .- 1759-9679. ; 9:20, s. 3019-3028
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- A new, rapid and sensitive on-line extraction and determination technique was developed with molecularly imprinted polymers (MIPs) in a packed cartridge. An artificial selective polymeric sorbents packed in a polyethylene cartridge were employed for the separation of sulfathiazole residue. The packing particles were synthesized using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker agent, sulfathiazole as a target template molecule and azobisisobutyronitrile as an initiator. The optimal conditions for designing these sorbents were as follows: conditioning using water with pH = 3.0, loading the sample under mild basic aqueous conditions, cleanup using 2 x 2 mL acetonitrile and elution with 3.0 mL 20 mM ammonium acetate : acetonitrile (75 : 25 v/v, pH = 3.0). In this system, an aliquot of extracted template was injected to the HPLC analytical column with acetonitrile : water (75 : 25 v/v) and water (pH adjusted to 3.0 with H3PO4) as the mobile phases in a gradient elution program. The selectivity of the MIPs in the packed cartridge was evaluated by checking several substances with molecular structures similar to that of the template. The results revealed a recovery of more than 92% along with a limit of detection and limit of quantification of 0.05 and 0.16 ng mL(-1), respectively, for the on-line determination of sulfathiazole in pharmaceutical wastewater samples.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Annan lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Other Agricultural Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Annan teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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