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Persistent organic ...
Persistent organic pollutants in infants and toddlers : Relationship between concentrations in matched plasma and faecal samples
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Chen, Yiqin (author)
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Sjodin, Andreas (author)
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- McLachlan, Michael S. (author)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
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English, Karin (author)
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Aylward, Lesa L. (author)
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Toms, Leisa-Maree L. (author)
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Varghese, Julie (author)
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Sly, Peter D. (author)
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Mueller, Jochen F. (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 107, s. 82-88
- Related links:
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https://eprints.qut....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13 +/- 4.8 months), including a repeat sample time point for 13 infants (similar to 5 months apart). We observed higher rates of POP quantification in faeces (2 g dry weight) than in plasma (0.5 mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (C-f) and blood (C-b) were correlated (r > 0.74, P < 0.05) for p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3', 4,4', 5-pentachlorobiphenyl (PCB118), 2,2', 3,4,4', 5'-pentachlorobiphenyl (PCB138) and 2,2', 4,4', 5,5'-pentachlorobiphenyl (PCB153). We determined faeces: plasma concentration ratios (K-fb), which can be used to estimate C-b from measurements of C-f for infants/toddlers. For a given chemical, the variation in K-fb across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in K-fb over the first year of life. The strong correlations between C-f and C-b demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in K-fb could improve the precision and utility of this technique.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
Keyword
- POPs
- Non-invasive bio-monitoring
- Infants
- Toddlers
- Faeces
- Blood
Publication and Content Type
- ref (subject category)
- art (subject category)
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