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Persistent organic ...
Persistent organic pollutants in infants and toddlers : Relationship between concentrations in matched plasma and faecal samples
- Article/chapterEnglish2017
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Elsevier BV,2017
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LIBRIS-ID:oai:DiVA.org:su-146949
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-146949URI
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https://doi.org/10.1016/j.envint.2017.06.019DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13 +/- 4.8 months), including a repeat sample time point for 13 infants (similar to 5 months apart). We observed higher rates of POP quantification in faeces (2 g dry weight) than in plasma (0.5 mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (C-f) and blood (C-b) were correlated (r > 0.74, P < 0.05) for p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3', 4,4', 5-pentachlorobiphenyl (PCB118), 2,2', 3,4,4', 5'-pentachlorobiphenyl (PCB138) and 2,2', 4,4', 5,5'-pentachlorobiphenyl (PCB153). We determined faeces: plasma concentration ratios (K-fb), which can be used to estimate C-b from measurements of C-f for infants/toddlers. For a given chemical, the variation in K-fb across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in K-fb over the first year of life. The strong correlations between C-f and C-b demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in K-fb could improve the precision and utility of this technique.
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Sjodin, Andreas
(author)
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McLachlan, Michael S.Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi(Swepub:su)mmcla
(author)
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English, Karin
(author)
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Aylward, Lesa L.
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Toms, Leisa-Maree L.
(author)
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Varghese, Julie
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Sly, Peter D.
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Mueller, Jochen F.
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Stockholms universitetInstitutionen för miljövetenskap och analytisk kemi
(creator_code:org_t)
Related titles
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In:Environment International: Elsevier BV107, s. 82-880160-41201873-6750
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