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  • Chen, Yiqin (author)

Persistent organic pollutants in infants and toddlers : Relationship between concentrations in matched plasma and faecal samples

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Elsevier BV,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-146949
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-146949URI
  • https://doi.org/10.1016/j.envint.2017.06.019DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13 +/- 4.8 months), including a repeat sample time point for 13 infants (similar to 5 months apart). We observed higher rates of POP quantification in faeces (2 g dry weight) than in plasma (0.5 mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (C-f) and blood (C-b) were correlated (r > 0.74, P < 0.05) for p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3', 4,4', 5-pentachlorobiphenyl (PCB118), 2,2', 3,4,4', 5'-pentachlorobiphenyl (PCB138) and 2,2', 4,4', 5,5'-pentachlorobiphenyl (PCB153). We determined faeces: plasma concentration ratios (K-fb), which can be used to estimate C-b from measurements of C-f for infants/toddlers. For a given chemical, the variation in K-fb across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in K-fb over the first year of life. The strong correlations between C-f and C-b demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in K-fb could improve the precision and utility of this technique.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sjodin, Andreas (author)
  • McLachlan, Michael S.Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi(Swepub:su)mmcla (author)
  • English, Karin (author)
  • Aylward, Lesa L. (author)
  • Toms, Leisa-Maree L. (author)
  • Varghese, Julie (author)
  • Sly, Peter D. (author)
  • Mueller, Jochen F. (author)
  • Stockholms universitetInstitutionen för miljövetenskap och analytisk kemi (creator_code:org_t)

Related titles

  • In:Environment International: Elsevier BV107, s. 82-880160-41201873-6750

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