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Mechanical Shieldin...
Mechanical Shielding of Rapidly Growing Cells Buffers Growth Heterogeneity and Contributes to Organ Shape Reproducibility
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Hervieux, Nathan (author)
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- Tsugawa, Satoru (author)
- Stockholms universitet,Matematiska institutionen,Hokkaido University, Japan
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Fruleux, Antoine (author)
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Dumond, Mathilde (author)
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Routier-Kierzkowska, Anne-Lise (author)
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Komatsuzaki, Tamiki (author)
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Boudaoud, Arezki (author)
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Larkin, John C. (author)
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Smith, Richard S. (author)
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- Li, Chun-Biu (author)
- Stockholms universitet,Matematiska institutionen,Hokkaido University, Japan
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Hamant, Olivier (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 27:22, s. 3468-3479.e4
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- A landmark of developmental biology is the production of reproducible shapes, through stereotyped morphogenetic events. At the cell level, growth is often highly heterogeneous, allowing shape diversity to arise. Yet, how can reproducible shapes emerge from such growth heterogeneity? Is growth heterogeneity filtered out? Here, we focus on rapidly growing trichome cells in the Arabidopsis sepal, a reproducible floral organ. We show via computational modeling that rapidly growing cells may distort organ shape. However, the cortical microtubule alignment along growth-derived maximal tensile stress in adjacent cells would mechanically isolate rapidly growing cells and limit their impact on organ shape. In vivo, we observed such microtubule response to stress and consistently found no significant effect of trichome number on sepal shape in wild-type and lines with trichome number defects. Conversely, modulating the microtubule response to stress in katanin and spiral2 mutant made sepal shape dependent on trichome number, suggesting that, while mechanical signals are propagated around rapidly growing cells, the resistance to stress in adjacent cells mechanically isolates rapidly growing cells, thus contributing to organ shape reproducibility.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hervieux, Nathan
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Tsugawa, Satoru
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Fruleux, Antoine
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Dumond, Mathilde
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Routier-Kierzkow ...
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Komatsuzaki, Tam ...
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show more...
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Boudaoud, Arezki
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Larkin, John C.
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Smith, Richard S ...
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Li, Chun-Biu
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Hamant, Olivier
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Current Biology
- By the university
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Stockholm University