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- Munoz-Alarcon, AndresSödertörns högskola,Institutionen för livsvetenskaper,Karolinska Institute (author)
Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- 2007-06-13
- Public Library of Science (PLoS),2007
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-16264
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16264URI
- https://doi.org/10.1371/journal.pone.0000532DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:119843664URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-14220URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function. Vertebrate A-type lamins are expressed in differentiating cells, while B-type lamins are expressed ubiquitously. Drosophila has two lamin genes that are expressed in A- and B-type patterns, and it is assumed that similarly expressed lamins perform similar functions. However, Drosophila and vertebrate lamins are not orthologous, and their expression patterns evolved independently. It is therefore of interest to examine the effects of mutations in lamin genes. Mutations in the mammalian lamin A/C gene cause a range of diseases, collectively called laminopathies, that include muscular dystrophies and premature aging disorders. We compared the sequences of lamin genes from different species, and we have characterized larval and adult phenotypes in Drosophila bearing mutations in the lam gene that is expressed in the B-type pattern. Larvae move less and show subtle muscle defects, and surviving lam adults are flightless and walk like aged wild-type flies, suggesting that lam phenotypes might result from neuromuscular defects, premature aging, or both. The resemblance of Drosophila lam phenotypes to human laminopathies suggests that some lamin functions may be performed by differently expressed genes in flies and mammals. Such still-unknown functions thus would not be dependent on lamin gene expression pattern, suggesting the presence of other lamin functions that are expression dependent. Our results illustrate a complex interplay between lamin gene expression and function through evolution.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- Biology
- Biologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Pavlovic, MajaSödertörns högskola,Institutionen för livsvetenskaper,Karolinska Institute (author)
- Wismar, JasmineMax-Planck-Institut für Hirnforschung, Frankfurt, Germany (author)
- Schmitt, BertramMax-Planck-Institut für Hirnforschung, Frankfurt, Germany (author)
- Eriksson, MariaKarolinska Institutet,Karolinska Institute (author)
- Kylsten, PerSödertörns högskola,Institutionen för livsvetenskaper(Swepub:sh)SHPRKN (author)
- Dushay, Mitchell S.Södertörns högskola,Uppsala universitet,Jämförande fysiologi,Institutionen för livsvetenskaper,Uppsala University(Swepub:sh)SHMHDY (author)
- Södertörns högskolaInstitutionen för livsvetenskaper (creator_code:org_t)
Related titles
- In:PLoS ONE: Public Library of Science (PLoS)2:6, s. e532-1932-6203
Internet link
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000532&type=printable
- https://doi.org/10.1371/journal.pone.0000532Fulltext
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-16264
- https://doi.org/10.1371/journal.pone.0000532
- http://kipublications.ki.se/Default.aspx?queryparsed=id:119843664
- https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-14220
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