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Heterogeneous Acid-...
Heterogeneous Acid-Catalyzed Racemization of Tertiary Alcohols
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- Görbe, Tamás (author)
- Stockholms universitet,Institutionen för organisk kemi
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- Lihammar, Richard (author)
- Stockholms universitet,Institutionen för organisk kemi
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- Bäckvall, Jan-E. (author)
- Stockholms universitet,Institutionen för organisk kemi
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(creator_code:org_t)
- 2017-11-30
- 2018
- English.
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In: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 24:1, s. 77-80
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Tertiary alcohols are important structural motifs in natural products and building blocks in organic synthesis but only few methods are known for their enantioselective preparation. Chiral resolution is one of these approaches that leaves one enantiomer (50% of the material) unaffected. An attractive method to increase the efficiency of those resolutions is to racemize the unaffected enantiomer. In the present work, we have developed a practical racemization protocol for tertiary alcohols. Five different acidic resin materials were tested. The Dowex 50WX8 was the resin of choice since it was capable of racemizing tertiary alcohols without any byproduct formation. Suitable solvents and a biphasic system were investigated, and the optimized system was capable of racemizing differently substituted tertiary alcohols.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- acidic resins
- heterogeneous catalysis
- racemization
- tertiary alcohols
- organisk kemi
- Organic Chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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