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Assessment of kalli...
Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease
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- Patra, Kalicharan (author)
- Stockholm University,Stockholms universitet,Institutionen för neurokemi
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- Soosaipillai, Antoninus (author)
- Mount Sinai Hospital of University of Toronto
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- Sando, Sigrid Botne (author)
- Norwegian University of Science and Technology,St. Olav’s University Hospital
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- Lauridsen, Camilla (author)
- Norwegian University of Science and Technology
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- Berge, Guro (author)
- Norwegian University of Science and Technology
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- Møller, Ina (author)
- Norwegian University of Science and Technology
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- Grontvedt, Gøril Rolfseng (author)
- Norwegian University of Science and Technology
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- Bråthen, Geir (author)
- Norwegian University of Science and Technology,St. Olav’s University Hospital
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- Begcevic, Ilijana (author)
- Mount Sinai Hospital of University of Toronto
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- Moussaud, Simon (author)
- Stockholm University,Karolinska Institutet,Stockholms universitet,Institutionen för neurokemi
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- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Diamandis, Eleftherios P. (author)
- Mount Sinai Hospital of University of Toronto
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- White, Linda R. (author)
- Norwegian University of Science and Technology,St. Olav’s University Hospital
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- Nielsen, Henrietta M. (author)
- Stockholm University,Stockholms universitet,Institutionen för neurokemi
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(creator_code:org_t)
- 2018-01-29
- 2018
- English.
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In: Alzheimer's Research & Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 10
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https://alzres.biome...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background: Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in neurodegenerative diseases such as Alzheimer's disease (AD), prompting validation of KLK6 as a potential biomarker of disease. However, analyses of both plasma and cerebrospinal fluid (CSF) levels of KLK6 in patients with AD have been inconclusive. We present a detailed analysis of KLK6 in plasma and CSF in two separate cohorts in a cross-sectional and a longitudinal clinical setting. Methods: The cross-sectional cohort included control subjects without dementia and patients with AD, and the longitudinal cohort included patients with MCI and patients with AD followed over a 2-year period. Plasma and CSF levels of KLK6 were quantified by use of a previously developed and validated enzyme-linked immunosorbent assay. Statistical analyses were performed to compare KLK6 levels between diagnostic groups and to identify potential associations between KLK6 level, age, apolipoprotein E (APOE) genotype, total apoE level and the classical CSF AD biomarkers. Results: In the cross-sectional setting, KLK6 levels in plasma but not in CSF were significantly higher in the AD group than in control subjects. CSF but not plasma KLK6 levels were positively correlated with age in both the cross-sectional and longitudinal settings. In both cohorts, the CSF KLK6 levels were significantly and positively correlated with the CSF levels of core AD biomarkers. Total plasma and CSF apoE levels were positively associated with KLK6 in the cross-sectional study. Finally, during the 2-year monitoring period of the longitudinal cohort, CSF KLK6 levels increased with disease progression over time in the investigated patient groups. Conclusions: In two separate cohorts we have confirmed the previously reported correlation between age and CSF levels of KLK6. Increased plasma KLK6 levels in patients with AD with a more advanced disease stage suggest KLK6 as a potential biomarker in patients with AD with more severe dementia. Significant correlations between KLK6 levels and core CSF AD biomarkers suggest molecular links between KLK6 and AD-related pathological processes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- KLK6
- Neurosin
- Biomarker
- Neurodegeneration
- Alzheimer's disease
- Alzheimer's disease
- Biomarker
- KLK6
- Neurodegeneration
- Neurosin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Patra, Kalichara ...
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Soosaipillai, An ...
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Sando, Sigrid Bo ...
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Lauridsen, Camil ...
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Berge, Guro
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Møller, Ina
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Grontvedt, Gøril ...
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Bråthen, Geir
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Begcevic, Ilijan ...
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Moussaud, Simon
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Minthon, Lennart
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Hansson, Oskar
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Diamandis, Eleft ...
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White, Linda R.
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Nielsen, Henriet ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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Alzheimer's Rese ...
- By the university
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Stockholm University
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Karolinska Institutet
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Lund University