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Metals and Parkinso...
Metals and Parkinson's Disease : Mechanisms and Biochemical Processes
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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Bentham Science Publishers Ltd.2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-157752
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-157752URI
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https://doi.org/10.2174/0929867325666171129124616DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Stejskal, VeraStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
(author)
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Urbina, Mauricio A.
(author)
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Dadar, Maryam
(author)
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Chirumbolo, Salvatore
(author)
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Mutter, Joachim
(author)
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Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
Related titles
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In:Current Medicinal Chemistry: Bentham Science Publishers Ltd.25:19, s. 2198-22140929-86731875-533X
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