Metals and Parkinson's Disease: Mechanisms and Biochemical Processes

Metals and Parkinson's Disease : Mechanisms and Biochemical Processes

Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.

Stejskal, VeraStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut (author)
Urbina, Mauricio A. (author)
Dadar, Maryam (author)
Chirumbolo, Salvatore (author)
Mutter, Joachim (author)
Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

In:Current Medicinal Chemistry: Bentham Science Publishers Ltd.25:19, s. 2198-22140929-86731875-533X

By the author/editor: Bjorklund, Geir; Stejskal, Vera; Urbina, Mauricio ...; Dadar, Maryam; Chirumbolo, Salv ...; Mutter, Joachim

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Medical Biotechn ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medicinal Chemis ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.