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Longitudinal uncoup...
Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease
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- Leuzy, Antoine (author)
- Karolinska Institutet
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- Rodriguez-Vieitez, Elena (author)
- Karolinska Institutet
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Saint-Aubert, Laure (author)
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- Chiotis, Konstantinos (author)
- Karolinska Institutet
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- Almkvist, Ove (author)
- Stockholms universitet,Biologisk psykologi,Karolinska Institutet, Sweden; Karolinska University Hospital, Sweden
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Savitcheva, Irina (author)
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- Jonasson, My (author)
- Uppsala universitet,Radiologi,Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden
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- Lubberink, Mark (author)
- Uppsala universitet,Radiologi,Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden
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- Wall, Anders (author)
- Uppsala universitet,Radiologi,Institutionen för läkemedelskemi
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- Antoni, Gunnar (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Nordberg, Agneta (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2017-12-18
- 2018
- English.
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In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 14:5, s. 652-663
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Abstract
Subject headings
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- Introduction: Cross-sectional findings using the tau tracer [F-18] THK5317 (THK5317) have shown that [F-18]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early-frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single PET study can provide both functional and molecular information. Methods: We included 16 patients with Alzheimer's disease who completed follow-up THK5317 and FDG studies 17 months after baseline investigations. Linear mixed-effects models and annual percentage change maps were used to examine longitudinal change. Results: Limited spatial overlap was observed between areas showing declines in THK5317 perfusion measures and FDG. Minimal overlap was seen between areas showing functional change and those showing increased retention of THK5317. Discussion: Our findings suggest a spatiotemporal offset between functional changes and tau pathology and a partial uncoupling between perfusion and metabolism, possibly as a function of Alzheimer's disease severity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Positron emission tomography (PET)
- Tau imaging
- THK5317
- Neurofibrillary tangles
- FDG
- Hypometabolism
- Perfusion imaging
- R-1
- Perfusion SUVR
- Alzheimer's disease
- Prodromal Alzheimer's disease
- Alzheimer's disease dementia
- Mild cognitive impairment
- Longitudinal study
- Psychology
- psykologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Leuzy, Antoine
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Rodriguez-Vieite ...
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Saint-Aubert, La ...
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Chiotis, Konstan ...
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Almkvist, Ove
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Savitcheva, Irin ...
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show more...
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Jonasson, My
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Lubberink, Mark
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Wall, Anders
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Antoni, Gunnar
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Nordberg, Agneta
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Stockholm University
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Karolinska Institutet
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Uppsala University