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Epidermal Growth Fa...
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development
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- Binder, Zev A. (author)
- Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.
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- Haseley Thorne, Amy (author)
- Ludwig Inst Canc Res, San Diego, CA 92093 USA.
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- Bakas, Spyridon (author)
- Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
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- Wileyto, E. Paul (author)
- Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
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- Bilello, Michel (author)
- Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
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- Akbari, Hamed (author)
- Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
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- Rathore, Saima (author)
- Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
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- Ha, Sung Min (author)
- Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
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- Zhang, Logan (author)
- Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.
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- Ferguson, Cole J. (author)
- Washington Univ, Div Neuropathol, Dept Pathol & Immunol, Sch Med, St Louis, MO 63108 USA.
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- Dahiya, Sonika (author)
- Washington Univ, Div Neuropathol, Dept Pathol & Immunol, Sch Med, St Louis, MO 63108 USA.
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- Bi, Wenya Linda (author)
- Brigham & Womans Hosp, Harvard Med Ctr, Dept Neurosurg, Ctr Skull Base & Pituitary Surg, Boston, MA 02115 USA.
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- Reardon, David A. (author)
- Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA 02215 USA.
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- Idbaih, Ahmed (author)
- Sorbonne Univ, Hop Univ Pitie Salpetriere Charles Foix, AP HP, Serv Neurol Mazarin 2, Inserm,CNRS,UMR S 1127, F-75013 Paris, France.
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- Felsberg, Joerg (author)
- Heinrich Heine Univ, Inst Neuropathol, Med Fac, Moorenstr 5, D-40225 Dusseldorf, Germany.
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- Hentschel, Bettina (author)
- Univ Leipzig, Med Fac, Inst Med Informat Stat & Epidemiol, Hartelstr 16, D-04107 Leipzig, Germany.
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- Weller, Michael (author)
- Univ Hosp, Dept Neurol, CH-8091 Zurich, Switzerland.;Univ Zurich, CH-8091 Zurich, Switzerland.
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- Bagley, Stephen J. (author)
- Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
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- Morrissette, Jennifer J. D. (author)
- Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA.
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- Nasrallah, MacLean P. (author)
- Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Div Neuropathol, Philadelphia, PA 19104 USA.
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Ma, Jianhui (author)
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Zanca, Ciro (author)
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- Scott, Andrew M. (author)
- La Trobe Univ, Olivia Newton John Canc Res Inst, Melbourne, Vic, Australia.
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- Orellana, Laura (author)
- KTH,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Science for Life Laboratory, SciLifeLab,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
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Davatzikos, Christos (author)
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- Furnari, Frank B. (author)
- Ludwig Inst Canc Res, San Diego, CA 92093 USA.
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- O'Rourke, Donald M. (author)
- Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
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Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA. Ludwig Inst Canc Res, San Diego, CA 92093 USA. (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 34:1, s. 163-177
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR) extracellular domain missense mutations. Retrospective assessment of 260 de novo glioblastoma patients revealed a significant reduction in overall survival of patients having tumors with EGFR mutations at alanine 289 (EGFR(A289D/T/V)). Quantitative multi-parametric magnetic resonance imaging analyses indicated increased tumor invasion for EGFR(A289D/T/V) mutants, corroborated in mice bearing intracranial tumors expressing EGFR(A289V) and dependent on ERK-mediated expression of matrix metalloproteinase-1. EGFR(A289V) tumor growth was attenuated with an antibody against a cryptic epitope, based on in silico simulation. The findings of this study indicate a highly invasive phenotype associated with the EGFR(A289V) mutation in glioblastoma, postulating EGFR(A289V) as a molecular marker for responsiveness to therapy with EGFR-targeting antibodies.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Binder, Zev A.
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Haseley Thorne, ...
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Bakas, Spyridon
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Wileyto, E. Paul
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Bilello, Michel
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Akbari, Hamed
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show more...
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Rathore, Saima
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Ha, Sung Min
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Zhang, Logan
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Ferguson, Cole J ...
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Dahiya, Sonika
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Bi, Wenya Linda
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Reardon, David A ...
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Idbaih, Ahmed
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Felsberg, Joerg
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Hentschel, Betti ...
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Weller, Michael
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Bagley, Stephen ...
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Morrissette, Jen ...
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Nasrallah, MacLe ...
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Ma, Jianhui
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Zanca, Ciro
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Scott, Andrew M.
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Orellana, Laura
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Davatzikos, Chri ...
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Furnari, Frank B ...
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O'Rourke, Donald ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Cancer Cell
- By the university
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Stockholm University
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Royal Institute of Technology