Search: onr:"swepub:oai:DiVA.org:su-159114" >
Epidermal Growth Fa...
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Binder, Zev A.Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.
(author)
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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Elsevier BV,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-159114
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-159114URI
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https://doi.org/10.1016/j.ccell.2018.06.006DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-232613URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20180730
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We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR) extracellular domain missense mutations. Retrospective assessment of 260 de novo glioblastoma patients revealed a significant reduction in overall survival of patients having tumors with EGFR mutations at alanine 289 (EGFR(A289D/T/V)). Quantitative multi-parametric magnetic resonance imaging analyses indicated increased tumor invasion for EGFR(A289D/T/V) mutants, corroborated in mice bearing intracranial tumors expressing EGFR(A289V) and dependent on ERK-mediated expression of matrix metalloproteinase-1. EGFR(A289V) tumor growth was attenuated with an antibody against a cryptic epitope, based on in silico simulation. The findings of this study indicate a highly invasive phenotype associated with the EGFR(A289V) mutation in glioblastoma, postulating EGFR(A289V) as a molecular marker for responsiveness to therapy with EGFR-targeting antibodies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Haseley Thorne, AmyLudwig Inst Canc Res, San Diego, CA 92093 USA.
(author)
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Bakas, SpyridonUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
(author)
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Wileyto, E. PaulUniv Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
(author)
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Bilello, MichelUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
(author)
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Akbari, HamedUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
(author)
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Rathore, SaimaUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
(author)
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Ha, Sung MinUniv Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
(author)
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Zhang, LoganUniv Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.
(author)
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Ferguson, Cole J.Washington Univ, Div Neuropathol, Dept Pathol & Immunol, Sch Med, St Louis, MO 63108 USA.
(author)
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Dahiya, SonikaWashington Univ, Div Neuropathol, Dept Pathol & Immunol, Sch Med, St Louis, MO 63108 USA.
(author)
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Bi, Wenya LindaBrigham & Womans Hosp, Harvard Med Ctr, Dept Neurosurg, Ctr Skull Base & Pituitary Surg, Boston, MA 02115 USA.
(author)
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Reardon, David A.Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA 02215 USA.
(author)
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Idbaih, AhmedSorbonne Univ, Hop Univ Pitie Salpetriere Charles Foix, AP HP, Serv Neurol Mazarin 2, Inserm,CNRS,UMR S 1127, F-75013 Paris, France.
(author)
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Felsberg, JoergHeinrich Heine Univ, Inst Neuropathol, Med Fac, Moorenstr 5, D-40225 Dusseldorf, Germany.
(author)
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Hentschel, BettinaUniv Leipzig, Med Fac, Inst Med Informat Stat & Epidemiol, Hartelstr 16, D-04107 Leipzig, Germany.
(author)
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Weller, MichaelUniv Hosp, Dept Neurol, CH-8091 Zurich, Switzerland.;Univ Zurich, CH-8091 Zurich, Switzerland.
(author)
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Bagley, Stephen J.Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
(author)
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Morrissette, Jennifer J. D.Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA.
(author)
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Nasrallah, MacLean P.Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Div Neuropathol, Philadelphia, PA 19104 USA.
(author)
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Ma, Jianhui
(author)
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Zanca, Ciro
(author)
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Scott, Andrew M.La Trobe Univ, Olivia Newton John Canc Res Inst, Melbourne, Vic, Australia.
(author)
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Orellana, LauraKTH,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Science for Life Laboratory, SciLifeLab,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden(Swepub:kth)u107xt9t
(author)
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Davatzikos, Christos
(author)
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Furnari, Frank B.Ludwig Inst Canc Res, San Diego, CA 92093 USA.
(author)
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O'Rourke, Donald M.Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.;Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
(author)
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Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA.Ludwig Inst Canc Res, San Diego, CA 92093 USA.
(creator_code:org_t)
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In:Cancer Cell: Elsevier BV34:1, s. 163-1771535-61081878-3686
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Binder, Zev A.
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Haseley Thorne, ...
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Bakas, Spyridon
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Wileyto, E. Paul
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Bilello, Michel
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Akbari, Hamed
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Rathore, Saima
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Ha, Sung Min
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Zhang, Logan
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Ferguson, Cole J ...
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Dahiya, Sonika
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Bi, Wenya Linda
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Reardon, David A ...
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Idbaih, Ahmed
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Felsberg, Joerg
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Hentschel, Betti ...
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Weller, Michael
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Bagley, Stephen ...
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Morrissette, Jen ...
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Nasrallah, MacLe ...
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Ma, Jianhui
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Zanca, Ciro
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Scott, Andrew M.
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Orellana, Laura
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Davatzikos, Chri ...
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Furnari, Frank B ...
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O'Rourke, Donald ...
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