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Amyloid-beta Peptid...
Amyloid-beta Peptide Interactions with Amphiphilic Surfactants : Electrostatic and Hydrophobic Effects
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- Österlund, Nicklas (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Institutionen för miljövetenskap och analytisk kemi,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs, S-10691 Stockholm, Sweden;Stockholm Univ, Dept Environm Sci & Analyt Chem, Arrhenius Labs, S-10691 Stockholm, Sweden
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- Kulkarni, Yashraj S. (author)
- Uppsala universitet,Strukturbiologi
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- Misiaszek, Agata D. (author)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi
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- Wallin, Cecilia (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs, S-10691 Stockholm, Sweden
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- Krüger, Dennis M. (author)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi
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- Liao, Qinghua (author)
- Uppsala universitet,Strukturbiologi
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- Mashayekhy Rad, Farshid (author)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Stockholm Univ, Dept Environm Sci & Analyt Chem, Arrhenius Labs, S-10691 Stockholm, Sweden
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- Jarvet, Jüri (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs, S-10691 Stockholm, Sweden;NICPB, EE-12618 Tallinn, Estonia
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- Strodel, Birgit (author)
- Forschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany
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- Wärmländer, Sebastian K. T. S. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs, S-10691 Stockholm, Sweden
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- Ilag, Leopold L. (author)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Stockholm Univ, Dept Environm Sci & Analyt Chem, Arrhenius Labs, S-10691 Stockholm, Sweden
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- Kamerlin, Shina C. L., 1981- (author)
- Uppsala universitet,Strukturbiologi
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- Gräslund, Astrid (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs, S-10691 Stockholm, Sweden
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(creator_code:org_t)
- 2018-04-23
- 2018
- English.
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In: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 9:7, s. 1680-1692
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The amphiphilic nature of the amyloid-beta (A beta) peptide associated with Alzheimer's disease facilitates various interactions with biomolecules such as lipids and proteins, with effects on both structure and toxicity of the peptide. Here, we investigate these peptide-amphiphile interactions by experimental and computational studies of A beta(1-40) in the presence of surfactants with varying physicochemical properties. Our findings indicate that electrostatic peptide-surfactant interactions are required for coclustering and structure induction in the peptide and that the strength of the interaction depends on the surfactant net charge. Both aggregation-prone peptide-rich coclusters and stable surfactant-rich coclusters can form. Only A beta(1-40) monomers, but not oligomers, are inserted into surfactant micelles in this surfactant-rich state. Surfactant headgroup charge is suggested to be important as electrostatic peptide-surfactant interactions on the micellar surface seems to be an initiating step toward insertion. Thus, no peptide insertion or change in peptide secondary structure is observed using a nonionic surfactant. The hydrophobic peptide-surfactant interactions instead stabilize the A beta monomer, possibly by preventing self-interaction between the peptide core and C terminus, thereby effectively inhibiting the peptide aggregation process. These findings give increased understanding regarding the molecular driving forces for A beta aggregation and the peptide interaction with amphiphilic biomolecules.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Alzheimer's disease
- A beta aggregation
- surfactant interactions
- optical and NMR spectroscopy
- mass spectrometry
- molecular dynamics simulations
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Österlund, Nickl ...
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Kulkarni, Yashra ...
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Misiaszek, Agata ...
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Wallin, Cecilia
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Krüger, Dennis M ...
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Liao, Qinghua
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show more...
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Mashayekhy Rad, ...
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Jarvet, Jüri
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Strodel, Birgit
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Wärmländer, Seba ...
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Ilag, Leopold L.
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Kamerlin, Shina ...
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Gräslund, Astrid
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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ACS Chemical Neu ...
- By the university
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Stockholm University
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Uppsala University