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Consequences of ano...
Consequences of anorectal cancer atlas implementation in the cooperative group setting : Radiobiologic analysis of a prospective randomized in silico target delineation study
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- Mavroidis, Panayiotis (author)
- Stockholms universitet,Fysikum,The University of Texas Health Science Center at San Antonio, USA; Karolinska Institutet, Sweden
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Giantsoudis, Drosoula (author)
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Awan, Musaddiq J. (author)
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Nijkamp, Jasper (author)
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Rasch, Coen R. N. (author)
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Duppen, Joop C. (author)
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Thomas, Charles R. (author)
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Okunieff, Paul (author)
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Jones, William E. (author)
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Kachnic, Lisa A. (author)
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Papanikolaou, Niko (author)
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Fuller, Clifton D. (author)
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Commit, SOGRO (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 112:3, s. 418-424
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: The aim of this study is to ascertain the subsequent radiobiological impact of using a consensus guideline target volume delineation atlas.Materials and methods: Using a representative case and target volume delineation instructions derived from a proposed IMRT rectal cancer clinical trial, gross tumor volume (GTV) and clinical/planning target volumes (CTV/PTV) were contoured by 13 physician observers (Phase 1). The observers were then randomly assigned to follow (atlas) or not-follow (control) a consensus guideline/atlas for anorectal cancers, and instructed to re-contour the same case (Phase 2).Results: The atlas group was found to have increased tumor control probability (TCP) after the atlas intervention for both the CTV (p < 0.0001) and PTV1 (p = 0.0011) with decreasing normal tissue complication probability (NTCP) for small intestine, while the control group did not. Additionally, the atlas group had reduced variance in TCP for all target volumes and reduced variance in NTCP for the bowel. In Phase 2, the atlas group had increased TCP relative to the control for CTV (p = 0.03).Conclusions: Visual atlas and consensus treatment guideline usage in the development of rectal cancer IMRT treatment plans reduced the inter-observer radiobiological variation, with clinically relevant TCP alteration for CTV and PTV volumes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Anorectal cancer
- Target delineation
- Radiobiological analysis
- Atlas implementation
- Inter-observer variation
Publication and Content Type
- ref (subject category)
- art (subject category)
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Mavroidis, Panay ...
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Giantsoudis, Dro ...
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Awan, Musaddiq J ...
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Nijkamp, Jasper
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Rasch, Coen R. N ...
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Duppen, Joop C.
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show more...
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Thomas, Charles ...
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Okunieff, Paul
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Jones, William E ...
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Kachnic, Lisa A.
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Papanikolaou, Ni ...
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Fuller, Clifton ...
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Commit, SOGRO
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Radiotherapy and ...
- By the university
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Stockholm University
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Karolinska Institutet