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Insertion Defects o...
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Vargas Möller-Hergt, BraulioStockholms universitet,Institutionen för biokemi och biofysik
(author)
Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-10-17
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MDPI AG,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-162935
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-162935URI
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https://doi.org/10.3390/cells7100172DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The mitochondrial proteome contains proteins from two different genetic systems. Proteins are either synthesized in the cytosol and imported into the different compartments of the organelle or directly produced in the mitochondrial matrix. To ensure proteostasis, proteins are monitored by the mitochondrial quality control system, which will degrade non-native polypeptides. Defective mitochondrial membrane proteins are degraded by membrane-bound AAA-proteases. These proteases are regulated by factors promoting protein turnover or preventing their degradation. Here we determined genetic interactions between the mitoribosome receptors Mrx15 and Mba1 with the quality control system. We show that simultaneous absence of Mrx15 and the regulators of the i-AAA protease Mgr1 and Mgr3 provokes respiratory deficiency. Surprisingly, mutants lacking Mrx15 were more tolerant against proteotoxic stress. Furthermore, yeast cells became hypersensitive against proteotoxic stress upon deletion of MBA1. Contrary to Mrx15, Mba1 cooperates with the regulators of the m-AAA and i-AAA proteases. Taken together, these results suggest that membrane protein insertion and mitochondrial AAA-proteases are functionally coupled, possibly reflecting an early quality control step during mitochondrial protein synthesis.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Carlström, AndreasStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)anca6695
(author)
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Suhm, TamaraStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)tsuhm
(author)
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Ott, MartinStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)mott
(author)
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Stockholms universitetInstitutionen för biokemi och biofysik
(creator_code:org_t)
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In:Cells: MDPI AG7:102073-4409
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