The association between anxiety, traumatic stress, and obsessive-compulsive disorders and chronic inflammation: A systematic review and meta-analysis

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Renna, Megan E. (author)

The association between anxiety, traumatic stress, and obsessive-compulsive disorders and chronic inflammation : A systematic review and meta-analysis

Article/chapterEnglish2018

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2018-09-10
Hindawi Limited,2018
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LIBRIS-ID:oai:DiVA.org:su-162993
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-162993URI
https://doi.org/10.1002/da.22790DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:139570403URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Background Methods Anxiety is characterized by prolonged preparation for real or perceived threat. This may manifest both as psychological and physiological activation, ultimately leading to greater risk for poor health. Chronic inflammation may play an integral role in this relationship, given the influential role that it has in chronic illness. The aim of this meta-analysis is to examine levels of chronic inflammation, measured by inflammatory cytokines and C-reactive protein, in people with anxiety disorders, PTSD (posttraumatic stress disorder), or obsessive-compulsive disorder compared to healthy controls. Several moderating variables, including specific diagnosis and depression comorbidity, were also assessed. Seventy six full-text articles were screened for eligibility with 41 studies ultimately included in analysis. Results Conclusions Results demonstrated a significant overall difference between healthy controls (HCs) and people with anxiety disorders in pro-inflammatory cytokines (P = 0.013, Hedge's g = -0.39), which appears to be largely driven by interleukin-1 beta (IL-1 beta; P = 0.009, Hedge's g = -0.50), IL-6 (P < 0.001, Hedge's g = -0.93), and tumor necrosis factor-alpha (P = 0.030, Hedge's g = -0.56). Moderation analyses revealed a moderating effect of diagnosis (P = 0.050), as only individuals with PTSD demonstrated differences in inflammation between HCs (P = 0.004, Hedge's g = -0.68). These data demonstrate the association between inflammatory dysregulation and diagnoses associated with chronic, impactful, and severe anxiety and provides insight into the way that anxiety, and in particular PTSD, is related to certain inflammatory markers. In doing so, these findings may provide an initial step in disentangling the relationship between anxiety and basic health processes.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
SAMHÄLLSVETENSKAP Psykologi hsv//swe
SOCIAL SCIENCES Psychology hsv//eng
anxiety disorders
biological markers
OCD
PTSD
SAD

Added entries (persons, corporate bodies, meetings, titles ...)

O'Toole, Mia S. (author)
Spaeth, Phillip E. (author)
Lekander, MatsStockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden(Swepub:su)mleka (author)
Mennin, Douglas S. (author)
Stockholms universitetStressforskningsinstitutet (creator_code:org_t)

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In:Depression and anxiety (Print): Hindawi Limited35:11, s. 1081-10941091-42691520-6394

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By the author/editor: Renna, Megan E.; O'Toole, Mia S.; Spaeth, Phillip ...; Lekander, Mats; Mennin, Douglas ...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

SOCIAL SCIENCES: SOCIAL SCIENCES; and Psychology

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By the university: Stockholm University; Karolinska Institutet

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