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Latent-Profile Anal...
Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations
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- Lövdén, Martin (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Karalija, Nina, 1984- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Andersson, Micael (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Wåhlin, Anders (author)
- Umeå universitet,Radiofysik
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- Axelsson, Jan, 1966- (author)
- Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Köhncke, Ylva (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Jonasson, Lars S., 1983- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Enheten för demografi och åldrandeforskning (CEDAR)
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- Rieckmann, Anna (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Papenberg, Goran (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Garrett, Douglas D. (author)
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- Guitart-Masip, Marc (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Salami, Alireza (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Riklund, Katrine (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Bäckman, Lars (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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Lindenberger, Ulman (author)
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(creator_code:org_t)
- 2017-09-25
- 2018
- English.
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In: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 28:11, s. 3894-3907
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with C-11-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availability, particularly in striatum, was associated with poor performance, especially for working memory. Relative to the rest of the sample, this subgroup also had lower education, higher body-mass index, and lower resting-state connectivity between caudate nucleus and dorsolateral prefrontal cortex. We conclude that a smaller subset of individuals induces a multivariate non-linear association between dopamine D2/3R availability and cognitive performance in this group of older adults, and discuss potential reasons for these differences that await further empirical scrutiny.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Cognitive Performance
- dopamine D-2/3 Receptor Availability
- Heterogeneity
- Latent Profile Analysis
- Older Adults
- Working Memory
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lövdén, Martin
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Karalija, Nina, ...
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Andersson, Micae ...
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Wåhlin, Anders
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Axelsson, Jan, 1 ...
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Köhncke, Ylva
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show more...
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Jonasson, Lars S ...
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Rieckmann, Anna
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Papenberg, Goran
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Garrett, Douglas ...
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Guitart-Masip, M ...
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Salami, Alireza
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Riklund, Katrine
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Bäckman, Lars
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Nyberg, Lars, 19 ...
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Lindenberger, Ul ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Cerebral Cortex
- By the university
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Stockholm University
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Umeå University
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Karolinska Institutet