Search: onr:"swepub:oai:DiVA.org:su-163001" >
Latent-Profile Anal...
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Lövdén, MartinKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2017-09-25
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Oxford University Press (OUP),2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-163001
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-163001URI
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https://doi.org/10.1093/cercor/bhx253DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-153657URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139546311URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with C-11-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availability, particularly in striatum, was associated with poor performance, especially for working memory. Relative to the rest of the sample, this subgroup also had lower education, higher body-mass index, and lower resting-state connectivity between caudate nucleus and dorsolateral prefrontal cortex. We conclude that a smaller subset of individuals induces a multivariate non-linear association between dopamine D2/3R availability and cognitive performance in this group of older adults, and discuss potential reasons for these differences that await further empirical scrutiny.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Karalija, Nina,1984-Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)nine0001
(author)
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Andersson, MicaelUmeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)mian0001
(author)
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Wåhlin, AndersUmeå universitet,Radiofysik(Swepub:umu)arswan02
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Axelsson, Jan,1966-Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)jaax0004
(author)
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Köhncke, YlvaStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Jonasson, Lars S.,1983-Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Enheten för demografi och åldrandeforskning (CEDAR)(Swepub:umu)jojo0148
(author)
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Rieckmann, AnnaUmeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)anri0051
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Papenberg, GoranKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Garrett, Douglas D.
(author)
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Guitart-Masip, MarcKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Salami, AlirezaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Riklund, KatrineUmeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)kaah0001
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Bäckman, LarsKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)lany0001
(author)
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Lindenberger, Ulman
(author)
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Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
Related titles
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In:Cerebral Cortex: Oxford University Press (OUP)28:11, s. 3894-39071047-32111460-2199
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Lövdén, Martin
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Karalija, Nina, ...
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Andersson, Micae ...
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Wåhlin, Anders
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Axelsson, Jan, 1 ...
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Köhncke, Ylva
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Jonasson, Lars S ...
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Rieckmann, Anna
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Papenberg, Goran
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Guitart-Masip, M ...
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Salami, Alireza
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Riklund, Katrine
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Bäckman, Lars
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- MEDICAL AND HEALTH SCIENCES
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Cerebral Cortex
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Stockholm University
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Umeå University
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Karolinska Institutet