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ThermoMouse :
ThermoMouse : An In Vivo Model to Identify Modulators of UCP1 Expression in Brown Adipose Tissue
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Galmozzi, Andrea (författare)
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Sonne, Si B. (författare)
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Altshuler-Keylin, Svetlana (författare)
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Hasegawa, Yutaka (författare)
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Shinoda, Kosaku (författare)
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- Luijten, Ineke H. N., 1989- (författare)
- University of California, USA
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Won Chang, Jae (författare)
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Sharp, Louis Z. (författare)
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Cravatt, Benjamin F. (författare)
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Saez, Enrique (författare)
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Kajimura, Shingo (författare)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 9:5, s. 1584-1593
- Relaterad länk:
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https://doi.org/10.1...
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https://su.diva-port... (primary) (Raw object)
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Obesity develops when energy intake chronically exceeds energy expenditure. Because brown adipose tissue (BAT) dissipates energy in the form of heat, increasing energy expenditure by augmenting BAT-mediated thermogenesis may represent an approach to counter obesity and its complications. The ability of BAT to dissipate energy is dependent on expression of mitochondrial uncoupling protein 1 (UCP1). To facilitate the identification of pharmacological modulators of BAT UCP1 levels, which may have potential as antiobesity medications, we developed a transgenic model in which luciferase activity faithfully mimics endogenous UCP1 expression and its response to physiologic stimuli. Phenotypic screening of a library using cells derived from this model yielded a small molecule that increases UCP1 expression in brown fat cells and mice. Upon adrenergic stimulation, compound-treated mice showed increased energy expenditure. These tools offer an opportunity to identify pharmacologic modulators of UCP1 expression and uncover regulatory pathways that impact BAT-mediated thermogenesis.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- UCP1
- brown adipose tissue
- mouse model
- screening
- Luciferase
- Molecular Cellbiology
- molekylär cellbiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Galmozzi, Andrea
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Sonne, Si B.
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Altshuler-Keylin ...
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Hasegawa, Yutaka
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Shinoda, Kosaku
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Luijten, Ineke H ...
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visa fler...
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Won Chang, Jae
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Sharp, Louis Z.
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Cravatt, Benjami ...
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Saez, Enrique
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Kajimura, Shingo
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
- Artiklar i publikationen
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Cell Reports
- Av lärosätet
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Stockholms universitet