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Association of poly...
Association of polypharmacy and hyperpolypharmacy with frailty states : a systematic review and meta-analysis
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Palmer, Katie (author)
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Villani, Emanuele R. (author)
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- Vetrano, Davide L. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Università Cattolica del Sacro Cuore, Italy
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Cherubini, Antonio (author)
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Cruz-Jentoft, Alfonso J. (author)
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Curtin, Denis (author)
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Denkinger, Michael (author)
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Gutierrez-Valencia, Marta (author)
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Guðmundsson, Adalsteinn (author)
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Knol, Wilma (author)
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Mak, Diane V. (author)
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O'Mahony, Denis (author)
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Pazan, Farhad (author)
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Petrovic, Mirko (author)
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Rajkumar, Chakravarthi (author)
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Topinkova, Eva (author)
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Trevisan, Catarina (author)
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van der Cammen, Tischa J. M. (author)
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van Marum, Rob J. (author)
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Wehling, Martin (author)
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Ziere, Gijsbertus (author)
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Bernabei, Roberto (author)
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Onder, Graziano (author)
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Bakken, Marit (author)
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Baeyens, Jean-Pierre (author)
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Benetos, Athanase (author)
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Crome, Peter (author)
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Fruhwald, Tomas (author)
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Gallagher, Paul (author)
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Jackson, Stephen (author)
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Jansen, Paul (author)
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Knol, Wilma (author)
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O'Neill, Desmond (author)
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Pilotto, Alberto (author)
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Ronnemaa, Elina (author)
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Rosholm, Jens-Ulrik (author)
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Serra, Jose Antonio (author)
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Soulis, George (author)
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van der Velde, Nathalie (author)
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(creator_code:org_t)
- 2018-11-07
- 2019
- English.
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In: European Geriatric Medicine. - : Springer Science and Business Media LLC. - 1878-7649 .- 1878-7657. ; 10:1, s. 9-36
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: To investigate: (1) the cross-sectional association between polypharmacy, hyperpolypharmacy and presence of prefrailty or frailty; (2) the risk of incident prefrailty or frailty in persons with polypharmacy, and vice versa.Methods: A systematic review and meta-analysis was performed according to PRISMA guidelines. We searched PubMed, Web of Science, and Embase from 01/01/1998 to 5/2/2018. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting. Homogeneity was assessed with the I-2 statistic and publication bias with Egger's and Begg's tests.Results: Thirty-seven studies were included. The pooled proportion of polypharmacy in persons with prefrailty and frailty was 47% (95% CI 33-61) and 59% (95% CI 42-76), respectively. Increased odds ratio of polypharmacy were seen for prefrail (pooled OR=1.52; 95% CI 1.32-1.79) and frail persons (pooled OR=2.62, 95% CI 1.81-3.79). Hyperpolypharmacy was also increased in prefrail (OR=1.95; 95% CI 1.41-2.70) and frail (OR=6.57; 95% CI 9.57-10.48) persons compared to robust persons. Only seven longitudinal studies reported data on the risk of either incident prefrailty or frailty in persons with baseline polypharmacy. A significant higher odds of developing prefrailty was found in robust persons with polypharmacy (pooled OR=1.30; 95% CI 1.12-1.51). We found no papers investigating polypharmacy incidence in persons with prefrailty/frailty.Conclusions: Polypharmacy is common in prefrail and frail persons, and these individuals are also more likely to be on extreme drug regimens, i.e. hyperpolypharmacy, than robust older persons. More research is needed to investigate the causal relationship between polypharmacy and frailty syndromes, thereby identifying ways to jointly reduce drug burden and prefrailty/frailty in these individuals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- Frail
- Prefrail
- Polypharmacy
- Drugs
- Ageing
- Medications
- Hyperpolypharmacy
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Palmer, Katie
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Villani, Emanuel ...
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Vetrano, Davide ...
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Cherubini, Anton ...
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Cruz-Jentoft, Al ...
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Curtin, Denis
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show more...
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Denkinger, Micha ...
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Gutierrez-Valenc ...
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Guðmundsson, Ada ...
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Knol, Wilma
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Mak, Diane V.
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O'Mahony, Denis
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Pazan, Farhad
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Petrovic, Mirko
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Rajkumar, Chakra ...
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Topinkova, Eva
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Trevisan, Catari ...
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van der Cammen, ...
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van Marum, Rob J ...
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Wehling, Martin
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Ziere, Gijsbertu ...
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Bernabei, Robert ...
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Onder, Graziano
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Bakken, Marit
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Baeyens, Jean-Pi ...
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Benetos, Athanas ...
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Crome, Peter
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Fruhwald, Tomas
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Gallagher, Paul
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Jackson, Stephen
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Jansen, Paul
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O'Neill, Desmond
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Pilotto, Alberto
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Ronnemaa, Elina
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Rosholm, Jens-Ul ...
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Serra, Jose Anto ...
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Soulis, George
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van der Velde, N ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Social and Clini ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
- Articles in the publication
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European Geriatr ...
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Stockholm University
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Karolinska Institutet