Search: onr:"swepub:oai:DiVA.org:su-167588" >
Inhibition of Nucle...
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
-
- Ma, Jianhui (author)
- Univ Calif San Diego, Ludwig Inst Canc Res, San Diego Branch, 9500 Gilman Dr, La Jolla, CA 92093 USA. i, Jie; Cavenee, Webster K.; Kolodner, Richard D.; Chen, Clark C.; Furnari, Frank B.
-
Benite, Jorge A. (author)
-
Li, Jie (author)
-
show more...
-
Miki, Shunichiro (author)
-
de Albuquerqu, Claudio Ponte (author)
-
Galatro, Thais (author)
-
- Orellana, Laura (author)
- KTH,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),KTH Royal Institute of Technology, Sweden,Beräkningsbiofysik,Science for Life Laboratory, SciLifeLab
-
Zanca, Ciro (author)
-
Reed, Rachel (author)
-
Boyer, Antonia (author)
-
Koga, Tomoyuki (author)
-
Varki, Nissi M. (author)
-
Fenton, Tim R. (author)
-
Marie, Suely Kazue Nagahashi (author)
-
- Lindahl, Erik (author)
- KTH,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),KTH Royal Institute of Technology, Sweden,Beräkningsbiofysik,Science for Life Laboratory, SciLifeLab
-
Gahman, Timothy C. (author)
-
Shiau, Andrew K. (author)
-
Zhou, Huilin (author)
-
DeGroot, John (author)
-
Sulman, Erik P. (author)
-
Cavenee, Webster K. (author)
-
Kolodner, Richard D. (author)
-
Chen, Clark C. (author)
-
Furnari, Frank B. (author)
-
show less...
-
Univ Calif San Diego, Ludwig Inst Canc Res, San Diego Branch, 9500 Gilman Dr, La Jolla, CA 92093 USA i, Jie; Cavenee, Webster K.; Kolodner, Richard D.; Chen, Clark C.; Furnari, Frank B. Institutionen för biokemi och biofysik (creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 35:3, s. 504-518.e7
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance mediated by phosphorylation of PTEN on tyrosine 240 (pY240-PTEN) by FGFR2. pY240-PTEN is rapidly elevated and bound to chromatin through interaction with Ki-67 in response to IR treatment and facilitates the recruitment of RAD51 to promote DNA repair. Blocking Y240 phosphorylation confers radiation sensitivity to tumors and extends survival in GBM preclinical models. Y240F-Pten knockin mice showed radiation sensitivity. These results suggest that FGFR-mediated pY240-PTEN is a key mechanism of radiation resistance and is an actionable target for improving radiotherapy efficacy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ma, Jianhui
-
Benite, Jorge A.
-
Li, Jie
-
Miki, Shunichiro
-
de Albuquerqu, C ...
-
Galatro, Thais
-
show more...
-
Orellana, Laura
-
Zanca, Ciro
-
Reed, Rachel
-
Boyer, Antonia
-
Koga, Tomoyuki
-
Varki, Nissi M.
-
Fenton, Tim R.
-
Marie, Suely Kaz ...
-
Lindahl, Erik
-
Gahman, Timothy ...
-
Shiau, Andrew K.
-
Zhou, Huilin
-
DeGroot, John
-
Sulman, Erik P.
-
Cavenee, Webster ...
-
Kolodner, Richar ...
-
Chen, Clark C.
-
Furnari, Frank B ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Pharmacology and ...
- Articles in the publication
-
Cancer Cell
- By the university
-
Stockholm University
-
Royal Institute of Technology