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Serum Insulin and C...
Serum Insulin and Cognitive Performance in Older Adults : A Longitudinal Study
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- Hooshmand, Babak (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Ulm University Hospital, Germany
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Rusanen, Minna (author)
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- Ngandu, Tiia (author)
- Karolinska Institutet
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Leiviskä, Jaana (author)
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- Sindi, Shireen (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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von Arnim, Christine A. F. (author)
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Falkai, Peter (author)
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Soininen, Hilkka (author)
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Tuomilehto, Jaakko (author)
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- Kivipelto, Miia (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of Eastern Finland, Finland; Karolinska Institute, Sweden
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: American Journal of Medicine. - : Elsevier BV. - 0002-9343 .- 1555-7162. ; 132:3, s. 367-373
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- PurposeThe aim of this study was to examine the association of serum glucose, insulin, and insulin resistance with cognitive functioning 7 years later in a longitudinal population-based study of Finnish older adults.MethodsSerum glucose and insulin were measured at baseline in 269 dementia-free individuals aged 65-79 years, from the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study. Insulin resistance was estimated with the homeostasis model assessment (HOMA-IR). Participants were reexamined 7 years later, and global cognition, episodic memory, executive functioning, verbal expression, and psychomotor speed were assessed, both at baseline and at follow-up. Multiple linear regression was used to investigate the associations with cognitive performance at follow-up, after adjusting for several potential confounders, including common vascular risk factors.ResultsIn the multivariable-adjusted linear regression models, no associations of insulin resistance with cognitive functioning were observed. After excluding 19 incident dementia cases, higher baseline HOMA-IR values were related to worse performance in global cognition (beta [standard error (SE)] -.050 [0.02]; P =.043) and psychomotor speed (beta [SE] -.064 [. 03]; P = [.043]) 7 years later. Raised serum insulin levels were associated with lower scores on global cognition (b [SE] -.054 [.03]; P =.045) and tended to relate to poorer performance in psychomotor speed (beta [SE] -.061 [.03]; P =.070).ConclusionsSerum insulin and insulin resistance may be independent predictors of cognitive performance 7 years later in elderly individuals without dementia. Randomized controlled trials are needed to determine this issue.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Cognition
- Dementia
- Insulin
- Insulin resistance
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hooshmand, Babak
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Rusanen, Minna
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Ngandu, Tiia
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Leiviskä, Jaana
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Sindi, Shireen
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von Arnim, Chris ...
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show more...
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Falkai, Peter
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Soininen, Hilkka
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Tuomilehto, Jaak ...
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Kivipelto, Miia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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American Journal ...
- By the university
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Stockholm University
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Karolinska Institutet