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The viral protein c...
The viral protein corona directs viral pathogenesis and amyloid aggregation
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- Ezzat, Kariem (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Karolinska Institutet, Sweden
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- Pernemalm, Maria (author)
- Karolinska Institutet
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- Pålsson, Sandra (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Roberts, Thomas C. (author)
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- Järver, Peter (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Dondalska, Aleksandra (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Bestas, Burcu (author)
- Karolinska Institutet
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- Sobkowiak, Michal J. (author)
- Karolinska Institutet
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Levanen, Bettina (author)
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- Skold, Magnus (author)
- Karolinska Institutet
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Thompson, Elizabeth A. (author)
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- Saher, Osama (author)
- Karolinska Institutet
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Kari, Otto K. (author)
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Lajunen, Tatu (author)
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- Ekström, Eva Sverremark (author)
- Karolinska Institutet,Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Nilsson, Caroline (author)
- Karolinska Institutet
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Ishchenko, Yevheniia (author)
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Malm, Tarja (author)
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Wood, Matthew J. A. (author)
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Power, Ultan F. (author)
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- Masich, Sergej (author)
- Karolinska Institutet
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- Linden, Anders (author)
- Karolinska Institutet
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- Sandberg, Johan K. (author)
- Karolinska Institutet
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- Lehtio, Janne (author)
- Karolinska Institutet
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- Spetz, Anna-Lena (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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EL Andaloussi, Samir (author)
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(creator_code:org_t)
- 2019-05-27
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
- Related links:
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid beta-peptide (A beta(42)), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ezzat, Kariem
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Pernemalm, Maria
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Pålsson, Sandra
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Roberts, Thomas ...
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Järver, Peter
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Dondalska, Aleks ...
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show more...
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Bestas, Burcu
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Sobkowiak, Micha ...
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Levanen, Bettina
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Skold, Magnus
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Thompson, Elizab ...
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Saher, Osama
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Kari, Otto K.
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Lajunen, Tatu
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Ekström, Eva Sve ...
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Nilsson, Carolin ...
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Ishchenko, Yevhe ...
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Malm, Tarja
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Wood, Matthew J. ...
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Power, Ultan F.
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Masich, Sergej
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Linden, Anders
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Sandberg, Johan ...
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Lehtio, Janne
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Spetz, Anna-Lena
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EL Andaloussi, S ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
- Articles in the publication
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Nature Communica ...
- By the university
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Stockholm University
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Karolinska Institutet