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Race reporting and ...
Race reporting and disparities in clinical trials on Alzheimer's disease : A systematic review
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Canevelli, Marco (author)
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Bruno, Giuseppe (author)
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- Grande, Giulia (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Quarata, Federica (author)
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Raganato, Riccardo (author)
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Remiddi, Francesca (author)
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Valletta, Martina (author)
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Zaccaria, Valerio (author)
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Vanacore, Nicola (author)
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Cesari, Matteo (author)
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Neuroscience and Biobehavioral Reviews. - : Elsevier BV. - 0149-7634 .- 1873-7528. ; 101, s. 122-128
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: Race is an important health determinant and should adequately be considered in research and drug development protocols targeting Alzheimer's disease (AD).Methods: A systematic review of available randomized controlled trials (RCTs) on the currently marketed treatments for AD was conducted with the aim of 1) documenting the reporting of race, and 2) exploring the impact of race on the efficacy and safety/tolerability of the considered medications.Results: Overall, 59.2% of the 49 retained RCTs reported information concerning the race of participants. Only a striking minority of enrolled patients was constituted of blacks and Hispanics. None on the retained studies reported results on the efficacy and safety/tolerability of the tested treatment separately for racial groups nor performed sensitivity analyses accounting for the race of participants.Discussion: Race has insufficiently been reported in previous interventional studies on AD. Its potential association with the effectiveness and safety/tolerability of the tested medications has completely been neglected.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Sociologi -- Sociologi (hsv//swe)
- SOCIAL SCIENCES -- Sociology -- Sociology (hsv//eng)
Keyword
- Alzheimer's disease
- Dementia
- Race
- Randomized controlled trial
- External validity
- Precision medicine
Publication and Content Type
- ref (subject category)
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- By the author/editor
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Canevelli, Marco
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Bruno, Giuseppe
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Grande, Giulia
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Quarata, Federic ...
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Raganato, Riccar ...
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Remiddi, Frances ...
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Valletta, Martin ...
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Zaccaria, Valeri ...
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Vanacore, Nicola
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Cesari, Matteo
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Social and Clini ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Health Care Serv ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Sociology
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and Sociology
- Articles in the publication
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Neuroscience and ...
- By the university
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Stockholm University
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Karolinska Institutet