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A neurotoxin that s...
A neurotoxin that specifically targets Anopheles mosquitoes
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- Contreras, Estefania (author)
- University of California, Riverside
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- Masuyer, Geoffrey (author)
- Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik
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- Qureshi, Nadia (author)
- University of California, Riverside
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- Chawla, Swati (author)
- University of California, Riverside
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- Dhillon, Harpal S. (author)
- University of California, Riverside
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- Lee, Han Lim (author)
- Institute for Medical Research Kuala Lumpur
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- Chen, Jianwu (author)
- University of California, Riverside
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- Stenmark, Pål (author)
- Stockholm University,Lunds universitet,Stockholms universitet,Institutionen för biokemi och biofysik,Lund University, Sweden,Strukturell biokemi,Forskargrupper vid Lunds universitet,Structural Biochemistry,Lund University Research Groups
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- Gill, Sarjeet S. (author)
- University of California, Riverside
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(creator_code:org_t)
- 2019-06-28
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Abstract
Subject headings
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- Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution of clostridial neurotoxins and provides the basis for the use of P. bifermentans strains and PMP1 as innovative, environmentally friendly approaches to reduce malaria through anopheline control.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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