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PET imaging of amyl...
PET imaging of amyloid deposition in patients with mild cognitive impairment
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- Forsberg, Anton (author)
- Karolinska Institutet
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- Engler, Henry (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Almkvist, Ove (author)
- Stockholms universitet,Psykologiska institutionen,Karolinska Institutet, Sweden
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- Blomquist, Gunnar (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Hagman, Göran (author)
- Karolinska Institutet
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- Wall, Anders (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Ringheim, Anna (author)
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- Långström, Bengt (author)
- Uppsala universitet,Institutionen för biokemi och organisk kemi
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Nordberg, Agneta (author)
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 29:10, s. 1456-1465
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- It is of great clinical value to identify subjects at a high risk of developing AD. We previously found that the amyloid positron emission tomography (PET) tracer PIB showed a robust difference in retention in the brain between AD patients and healthy controls (HC). Twenty-one patients diagnosed with MCI (mean age 63.3 ± 7.8 (S.D.) years) underwent PET studies with 11C-PIB, and 18F-fluoro-deoxy-glucose (FDG) to measure cerebral glucose metabolism, as well as assessment of cognitive function and CSF sampling. Reference group data from 27 AD patients and 6 healthy controls, respectively, were used for comparison. The mean cortical PIB retention for the MCI patients was intermediate compared to HC and AD. Seven MCI patients that later at clinical follow-up converted to AD (8.1 ± 6.0 (S.D.) months) showed significant higher PIB retention compared to non-converting MCI patients and HC, respectively (ps < 0.01). The PIB retention in MCI converters was comparable to AD patients (p > 0.01). Correlations were observed in the MCI patients between PIB retention and CSF Aβ1-42, total Tau and episodic memory, respectively.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- mild cognitive impairment
- converters
- amyloid
- PET
- PIB
- FDG
- CSF biomarkers
- Psychology
- Psykologi
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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