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  • Forsberg, AntonKarolinska Institutet (author)

PET imaging of amyloid deposition in patients with mild cognitive impairment

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-17377
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-17377URI
  • https://doi.org/10.1016/j.neurobiolaging.2007.03.029DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117547617URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109078URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Financial support from the Swedish Research Council (project 05817, A.N.), the foundation for Old Servants (A.N.), Stohne's foundation (A.N.), the KI foundations (A.N.), the Alzheimer Foundation in Sweden (A.N.), Swedish Brain Power (A.N., B.L.), the EC-FP5-projec tNCI-MCI and the EC-FP6-project DiMI, LSHB-CT-2005-512146, QLK6-CT-2000-00502 (A.N.) is gratefully acknowledged.
  • It is of great clinical value to identify subjects at a high risk of developing AD. We previously found that the amyloid positron emission tomography (PET) tracer PIB showed a robust difference in retention in the brain between AD patients and healthy controls (HC). Twenty-one patients diagnosed with MCI (mean age 63.3 ± 7.8 (S.D.) years) underwent PET studies with 11C-PIB, and 18F-fluoro-deoxy-glucose (FDG) to measure cerebral glucose metabolism, as well as assessment of cognitive function and CSF sampling. Reference group data from 27 AD patients and 6 healthy controls, respectively, were used for comparison. The mean cortical PIB retention for the MCI patients was intermediate compared to HC and AD. Seven MCI patients that later at clinical follow-up converted to AD (8.1 ± 6.0 (S.D.) months) showed significant higher PIB retention compared to non-converting MCI patients and HC, respectively (ps < 0.01). The PIB retention in MCI converters was comparable to AD patients (p > 0.01). Correlations were observed in the MCI patients between PIB retention and CSF Aβ1-42, total Tau and episodic memory, respectively.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Engler, HenryUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)henrengl (author)
  • Almkvist, OveStockholms universitet,Psykologiska institutionen,Karolinska Institutet, Sweden(Swepub:su)almkv (author)
  • Blomquist, GunnarUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)gunnblom (author)
  • Hagman, GöranKarolinska Institutet (author)
  • Wall, AndersUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)andewall (author)
  • Ringheim, Anna (author)
  • Långström, BengtUppsala universitet,Institutionen för biokemi och organisk kemi (author)
  • Nordberg, Agneta (author)
  • Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Neurobiology of Aging: Elsevier BV29:10, s. 1456-14650197-45801558-1497

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