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  • Kadir, Ahmadul (author)

PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-17382
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-17382URI
  • https://doi.org/10.1016/j.neurobiolaging.2007.02.020DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110000URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117306962URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • This research was sponsored by the Medical Research Council (project no. 05817), Stiftelsen for Gamla Tjänarinnor, KI foundations, Stohne's foundation, and Janssen-Cilag (Sweden and USA).
  • The effect of galantamine treatment on cortical acetylcholinesterase (AChE) activity and nicotinic receptor binding was investigated by positron emission tomography (PET) in 18 patients with mild Alzheimer's disease (AD) in relation to galantamine concentration and the patients’ cognitive performances. The first 3 months of the study was of a randomized double-blind placebo-controlled design, during which 12 patients received galantamine (16–24 mg/day) and 6 patients the placebo, and this was followed by 9 months’ galantamine treatment in all patients. The patients underwent PET examinations to measure cortical AChE activity (11C-PMP) and 11C-nicotine binding. Neuropsychological tests were performed throughout the study. Inhibition (30–40%) of cortical AChE activity was observed after 3 weeks to 12 months of galantamine treatment. No significant change in mean cortical 11C-nicotine binding was observed during the study. 11C-Nicotine binding, however, positively correlated with plasma galantamine concentration. Both the changes of AChE activity and 11C-nicotine binding correlated positively with the results of a cognitive test of attention. In conclusion, galantamine caused sustained AChE inhibition for up to 12 months. At the individual level, the in vivo cortical AChE inhibition and 11C-nicotine binding were associated with changes in the attention domain of cognition rather than episodic memory.

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  • Darreh-Shori, T.Karolinska Institutet (author)
  • Almkvist, OveStockholms universitet,Psykologiska institutionen,Karolinska Institutet, Sweden(Swepub:su)almkv (author)
  • Wall, AndersUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)andewall (author)
  • Grut, M. (author)
  • Strandberg, B. (author)
  • Ringheim, A. (author)
  • Eriksson, B. (author)
  • Blomquist, G.Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi (author)
  • Långström, B. (author)
  • Nordberg, A.Karolinska Institutet (author)
  • Karolinska InstitutetPsykologiska institutionen (creator_code:org_t)

Related titles

  • In:Neurobiology of Aging: Elsevier BV29:8, s. 1204-12170197-45801558-1497

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