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Global phylogeograp...
Global phylogeography and ancient evolution of the widespread human gut virus crAssphage
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Edwards, Robert A. (author)
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Vega, Alejandro A. (author)
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Norman, Holly M. (author)
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show more...
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Ohaeri, Maria (author)
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Levi, Kyle (author)
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Dinsdale, Elizabeth A. (author)
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Cinek, Ondrej (author)
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Aziz, Ramy K. (author)
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McNair, Katelyn (author)
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Barr, Jeremy J. (author)
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Bibby, Kyle (author)
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Brouns, Stan J. J. (author)
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Cazares, Adrian (author)
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de Jonge, Patrick A. (author)
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Desnues, Christelle (author)
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Diaz Munoz, Samuel L. (author)
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Fineran, Peter C. (author)
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Kurilshikov, Alexander (author)
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Lavigne, Rob (author)
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Mazankova, Karla (author)
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McCarthy, David T. (author)
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Nobrega, Franklin L. (author)
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Reyes Munoz, Alejandro (author)
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Tapia, German (author)
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Trefault, Nicole (author)
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Tyakht, Alexander (author)
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Vinuesa, Pablo (author)
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Wagemans, Jeroen (author)
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Zhernakova, Alexandra (author)
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Aarestrup, Frank M. (author)
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Ahmadov, Gunduz (author)
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Alassaf, Abeer (author)
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Anton, Josefa (author)
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Asangba, Abigail (author)
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Billings, Emma K. (author)
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Cantu, Vito Adrian (author)
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Carlton, Jane M. (author)
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Cazares, Daniel (author)
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Cho, Gyu-Sung (author)
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Condeff, Tess (author)
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Cortes, Pilar (author)
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Cranfield, Mike (author)
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Cuevas, Daniel A. (author)
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De la Iglesia, Rodrigo (author)
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Decewicz, Przemyslaw (author)
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Doane, Michael P. (author)
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Dominy, Nathaniel J. (author)
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Dziewit, Lukasz (author)
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Elwasila, Bashir Mukhtar (author)
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Murat Eren, A. (author)
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Franz, Charles (author)
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Fu, Jingyuan (author)
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Garcia-Aljaro, Cristina (author)
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Ghedin, Elodie (author)
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Gulino, Kristen M. (author)
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Haggerty, John M. (author)
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Head, Steven R. (author)
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Hendriksen, Rene S. (author)
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Hill, Colin (author)
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Hyoty, Heikki (author)
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Ilina, Elena N. (author)
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Irwin, Mitchell T. (author)
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Jeffries, Thomas C. (author)
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Jofre, Juan (author)
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Junge, Randall E. (author)
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Kelley, Scott T. (author)
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Mirzaei, Mohammadali Khan (author)
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Kowalewski, Martin (author)
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Kumaresan, Deepak (author)
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Leigh, Steven R. (author)
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Lipson, David (author)
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Lisitsyna, Eugenia S. (author)
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Llagostera, Montserrat (author)
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Maritz, Julia M. (author)
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Marr, Linsey C. (author)
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McCann, Angela (author)
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Molshanski-Mor, Shahar (author)
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Monteiro, Silvia (author)
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Moreira-Grez, Benjamin (author)
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Morris, Megan (author)
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Mugisha, Lawrence (author)
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Muniesa, Maite (author)
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Neve, Horst (author)
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Nam-phuong, Nguyen (author)
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Nigro, Olivia D. (author)
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- Nilsson, Anders S. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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O'Connell, Taylor (author)
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Odeh, Rasha (author)
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Oliver, Andrew (author)
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Piuri, Mariana (author)
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Prussin, Aaron J. (author)
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Qimron, Udi (author)
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Quan, Zhe-Xue (author)
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Rainetova, Petra (author)
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Ramirez-Rojas, Adan (author)
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Raya, Raul (author)
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Reasor, Kim (author)
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Rice, Gillian A. O. (author)
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Rossi, Alessandro (author)
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Santos, Ricardo (author)
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Shimashita, John (author)
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Stachler, Elyse N. (author)
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Stene, Lars C. (author)
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Strain, Ronan (author)
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Stumpf, Rebecca (author)
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Torres, Pedro J. (author)
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Twaddle, Alan (author)
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Ibekwe, MaryAnn Ugochi (author)
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Villagra, Nicolas (author)
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Wandro, Stephen (author)
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White, Bryan (author)
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Whiteley, Andy (author)
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Whiteson, Katrine L. (author)
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Wijmenga, Cisca (author)
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Zambrano, Maria M. (author)
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Zschach, Henrike (author)
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Dutilh, Bas E. (author)
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(creator_code:org_t)
- 2019-07-08
- 2019
- English.
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In: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 4:10, s. 1727-1736
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Microbiomes are vast communities of microorganisms and viruses that populate all natural ecosystems. Viruses have been considered to be the most variable component of microbiomes, as supported by virome surveys and examples of high genomic mosaicism. However, recent evidence suggests that the human gut virome is remarkably stable compared with that of other environments. Here, we investigate the origin, evolution and epidemiology of crAssphage, a widespread human gut virus. Through a global collaboration, we obtained DNA sequences of crAssphage from more than one-third of the world's countries and showed that the phylogeography of crAssphage is locally clustered within countries, cities and individuals. We also found fully colinear crAssphage-like genomes in both Old-World and New-World primates, suggesting that the association of crAssphage with primates may be millions of years old. Finally, by exploiting a large cohort of more than 1,000 individuals, we tested whether crAssphage is associated with bacterial taxonomic groups of the gut microbiome, diverse human health parameters and a wide range of dietary factors. We identified strong correlations with different clades of bacteria that are related to Bacteroidetes and weak associations with several diet categories, but no significant association with health or disease. We conclude that crAssphage is a benign cosmopolitan virus that may have coevolved with the human lineage and is an integral part of the normal human gut virome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Edwards, Robert ...
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Vega, Alejandro ...
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Norman, Holly M.
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Ohaeri, Maria
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Levi, Kyle
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Dinsdale, Elizab ...
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show more...
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Cinek, Ondrej
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Aziz, Ramy K.
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McNair, Katelyn
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Barr, Jeremy J.
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Bibby, Kyle
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Brouns, Stan J. ...
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Cazares, Adrian
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de Jonge, Patric ...
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Desnues, Christe ...
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Diaz Munoz, Samu ...
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Fineran, Peter C ...
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Kurilshikov, Ale ...
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Lavigne, Rob
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Mazankova, Karla
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McCarthy, David ...
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Nobrega, Frankli ...
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Reyes Munoz, Ale ...
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Tapia, German
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Trefault, Nicole
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Tyakht, Alexande ...
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Vinuesa, Pablo
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Wagemans, Jeroen
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Zhernakova, Alex ...
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Aarestrup, Frank ...
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Ahmadov, Gunduz
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Alassaf, Abeer
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Anton, Josefa
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Asangba, Abigail
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Billings, Emma K ...
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Cantu, Vito Adri ...
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Carlton, Jane M.
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Cazares, Daniel
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Cho, Gyu-Sung
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Condeff, Tess
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Cortes, Pilar
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Cranfield, Mike
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Cuevas, Daniel A ...
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De la Iglesia, R ...
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Decewicz, Przemy ...
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Doane, Michael P ...
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Dominy, Nathanie ...
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Dziewit, Lukasz
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Elwasila, Bashir ...
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Murat Eren, A.
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Franz, Charles
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Fu, Jingyuan
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Garcia-Aljaro, C ...
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Ghedin, Elodie
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Gulino, Kristen ...
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Haggerty, John M ...
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Head, Steven R.
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Hendriksen, Rene ...
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Hill, Colin
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Hyoty, Heikki
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Ilina, Elena N.
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Irwin, Mitchell ...
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Jeffries, Thomas ...
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Jofre, Juan
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Junge, Randall E ...
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Kelley, Scott T.
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Mirzaei, Mohamma ...
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Kowalewski, Mart ...
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Kumaresan, Deepa ...
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Leigh, Steven R.
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Lipson, David
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Lisitsyna, Eugen ...
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Llagostera, Mont ...
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Maritz, Julia M.
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Marr, Linsey C.
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McCann, Angela
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Molshanski-Mor, ...
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Monteiro, Silvia
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Moreira-Grez, Be ...
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Morris, Megan
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Mugisha, Lawrenc ...
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Muniesa, Maite
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Neve, Horst
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Nam-phuong, Nguy ...
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Nigro, Olivia D.
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Nilsson, Anders ...
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O'Connell, Taylo ...
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Odeh, Rasha
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Oliver, Andrew
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Piuri, Mariana
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Prussin, Aaron J ...
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Qimron, Udi
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Quan, Zhe-Xue
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Rainetova, Petra
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Ramirez-Rojas, A ...
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Raya, Raul
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Reasor, Kim
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Rice, Gillian A. ...
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Rossi, Alessandr ...
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Santos, Ricardo
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Shimashita, John
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Stachler, Elyse ...
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Stene, Lars C.
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Strain, Ronan
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Stumpf, Rebecca
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Torres, Pedro J.
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Twaddle, Alan
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Ibekwe, MaryAnn ...
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Villagra, Nicola ...
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Wandro, Stephen
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White, Bryan
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Whiteley, Andy
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Whiteson, Katrin ...
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Wijmenga, Cisca
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Zambrano, Maria ...
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Zschach, Henrike
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Dutilh, Bas E.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Nature Microbiol ...
- By the university
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Stockholm University