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Prognosis and Inter...
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Zengarini, Elisa
(author)
Prognosis and Interplay of Cognitive Impairment and Sarcopenia in Older Adults Discharged from Acute Care Hospitals
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-10-15
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MDPI AG,2019
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LIBRIS-ID:oai:DiVA.org:su-176744
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-176744URI
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https://doi.org/10.3390/jcm8101693DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142382999URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Sarcopenia and cognitive impairment are associated with an increased risk of negative outcomes, but their prognostic interplay has not been investigated so far. We aimed to investigate the prognostic interaction of sarcopenia and cognitive impairment concerning 12-month mortality among older patients discharged from acute care wards in Italy. Our series consisted of 624 patients (age = 80.1 +/- 7.0 years, 56.1% women) enrolled in a prospective observational study. Sarcopenia was defined following the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. Cognitive impairment was defined as age- and education-adjusted Mini-Mental State Examination (MMSE) score < 24 or recorded diagnosis of dementia. The study outcome was all-cause mortality during 12-month follow-up. The combination of sarcopenia and cognitive ability was tested against participants with intact cognitive ability and without sarcopenia. Overall, 159 patients (25.5%) were identified as having sarcopenia, and 323 (51.8%) were cognitively impaired. During the follow-up, 79 patients (12.7%) died. After adjusting for potential confounders, the combination of sarcopenia and cognitive impairment has been found associated with increased mortality (HR = 2.12, 95% CI = 1.05-4.13). Such association was also confirmed after excluding patients with dementia (HR = 2.13, 95% CI = 1.06-4.17), underweight (HR = 2.18, 95% CI = 1.03-3.91), high comorbidity burden (HR = 2.63, 95% CI = 1.09-6.32), and severe disability (HR = 2.88, 95% CI = 1.10-5.73). The co-occurrence of sarcopenia and cognitive impairment may predict 1-year mortality in older patients discharged from acute care hospitals.
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Giacconi, Robertina
(author)
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Mancinelli, Lucia
(author)
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Riccardi, Giovanni Renato
(author)
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Castellani, Daniele
(author)
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Vetrano, Davide LiborioKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Istituto Superiore di Sanità, Italy
(author)
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Onder, Graziano
(author)
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Volpato, Stefano
(author)
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Ruggiero, Carmelinda
(author)
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Fabbietti, Paolo
(author)
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Cherubini, Antonio
(author)
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Guarasci, Francesco
(author)
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Corsonello, Andrea
(author)
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Lattanzio, Fabrizia
(author)
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Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
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In:Journal of Clinical Medicine: MDPI AG8:102077-0383
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Zengarini, Elisa
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Giacconi, Robert ...
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Mancinelli, Luci ...
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Riccardi, Giovan ...
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Castellani, Dani ...
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Vetrano, Davide ...
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Onder, Graziano
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Volpato, Stefano
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Ruggiero, Carmel ...
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Fabbietti, Paolo
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Cherubini, Anton ...
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Guarasci, France ...
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Corsonello, Andr ...
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Lattanzio, Fabri ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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Journal of Clini ...
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Stockholm University
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Karolinska Institutet