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Association of Leuk...
Association of Leukocyte Telomere Length with Mild Cognitive Impairment and Alzheimer's Disease : Role of Folate and Homocysteine
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Ma, Fei (author)
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Lv, Xin (author)
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Du, Yue (author)
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Chen, Hui (author)
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Liu, Shuai (author)
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Zhao, Jiangang (author)
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Gao, Yiming (author)
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An, Peilin (author)
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Zhou, Xuan (author)
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Song, Aili (author)
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Sun, Changqing (author)
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Wang, Guangshun (author)
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Ji, Yong (author)
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Wang, Xinyan (author)
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- Xu, Weili (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China; Center for International Collaborative Research on Environment, Nutrition and Public Health, China
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Huang, Guowei (author)
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(creator_code:org_t)
- 2019-08-22
- 2019
- English.
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In: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 48:1-2, s. 56-67
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Background: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and the role of folate and homocysteine (Hcy) in this relation remain unclear.Objectives: We aimed to investigate the association between LTL and the risks of MCI/AD, and to explore whether folate and Hcy may play a role in this association.Methods: This case-control study included 129 MCI subjects, 131 AD patients and 134 healthy controls. LTL was assessed using real-time polymerase chain reaction assay. Serum folate levels were tested by chemiluminescence enzyme immunoassay, and serum Hcy levels were measured using the enzymatic cycling method. Data were analyzed using multivariate logistic regression and multivariable linear regression with adjustment for potential confounders.Results: The mean LTL was 1.56 +/- 0.25 in controls, 1.44 +/- 0.23 in MCI, and 1.28 +/- 0.28 in AD patients (p< 0.01). In multivariate logistic regression, subjects in the longest LTL tertile had lower OR for MCI (OR 0.246; 95% CI 0.101-0.597) and AD (OR 0.123; 95% CI 0.044-0.345) in comparison to subjects in the shortest tertile. Shorter LTL was dose-dependently related to the ORs of MCI and AD. Further, serum folate concentration was positively associated with LTL (p < 0.01), while serum Hcy level was negatively associated with LTL (p < 0.05). In stratified analyses, LTL-MCI/AD association varied by serum folate and Hcy level. Conclusions: Shorter LTL is associated with the risks of MCI/AD. Folate and Hcy might play an important role in this association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Telomeres
- Alzheimer's disease
- Mild cognitive impairment
- Biological markers
- Case-control study
- neurologi
- Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ma, Fei
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Lv, Xin
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Du, Yue
-
Chen, Hui
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Liu, Shuai
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Zhao, Jiangang
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show more...
-
Gao, Yiming
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An, Peilin
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Zhou, Xuan
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Song, Aili
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Sun, Changqing
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Wang, Guangshun
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Ji, Yong
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Wang, Xinyan
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Xu, Weili
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Huang, Guowei
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Dementia and Ger ...
- By the university
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Stockholm University
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Karolinska Institutet