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Acyl-CoA-binding pr...
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Charmpilas, Nikolaos
(author)
Acyl-CoA-binding protein (ACBP) : a phylogenetically conserved appetite stimulator
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-01-06
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Springer Science and Business Media LLC,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-179638
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-179638URI
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https://doi.org/10.1038/s41419-019-2205-xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142903416URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Recently, we reported that, in mice, hunger causes the autophagy-dependent release of a protein called acyl-CoA-binding protein or diazepam binding inhibitor (ACBP/DBI) from cells, resulting in an increase in plasma ACBP concentrations. Administration of extra ACBP is orexigenic and obesogenic, while its neutralization is anorexigenic in mice, suggesting that ACBP is a major stimulator of appetite and lipo-anabolism. Accordingly, obese persons have higher circulating ACBP levels than lean individuals, and anorexia nervosa is associated with subnormal ACBP plasma concentrations. Here, we investigated whether ACBP might play a phylogenetically conserved role in appetite stimulation. We found that extracellular ACBP favors sporulation in Saccharomyces cerevisiae, knowing that sporulation is a strategy for yeast to seek new food sources. Moreover, in the nematode Caenorhabditis elegans, ACBP increased the ingestion of bacteria as well as the frequency pharyngeal pumping. These observations indicate that ACBP has a phylogenetically ancient role as a 'hunger factor' that favors food intake.
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Ruckenstuhl, Christoph
(author)
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Sica, Valentina
(author)
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Büttner, SabrinaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria(Swepub:su)sab
(author)
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Habernig, LukasStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)lhabe
(author)
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Dichtinger, Silvia
(author)
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Madeo, Frank
(author)
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Tavernarakis, Nektarios
(author)
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Bravo-San Pedro, José M.
(author)
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Kroemer, Guido
(author)
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Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
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In:Cell Death and Disease: Springer Science and Business Media LLC11:12041-4889
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Ruckenstuhl, Chr ...
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Sica, Valentina
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Büttner, Sabrina
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Habernig, Lukas
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Dichtinger, Silv ...
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Madeo, Frank
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Tavernarakis, Ne ...
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Karolinska Institutet