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The kidney injury c...
The kidney injury caused by the onset of acute graft-versus-host disease is associated with down-regulation of alpha Klotho
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- Amin, Risul (author)
- Karolinska Institutet
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- He, Rui (author)
- Karolinska Institutet
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- Gupta, Dhanu (author)
- Karolinska Institutet
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- Zheng, Wenyi (author)
- Karolinska Institutet
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- Burmakin, Mikhail (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Mohammad, Dara K. (author)
- Karolinska Institutet
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- DePierre, Joseph W. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Arrhenius Labs Nat Sci, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden
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- Sadeghi, Behnam (author)
- Karolinska Institutet
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- Olauson, Hannes (author)
- Karolinska Institutet
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- Wernerson, Annika (author)
- Karolinska Institutet
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- El-Andaloussi, Samir (author)
- Karolinska Institutet
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- Hassan, Moustapha (author)
- Karolinska Institutet
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- Abedi-Valugerdi, Manuchehr (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: International Immunopharmacology. - : Elsevier BV. - 1567-5769 .- 1878-1705. ; 78
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Acute graft-versus-host disease (aGVHD) and kidney injury are the major complications after allogeneic hematopoietic stem cell transplantation (HSCT). Although the underlying mechanisms for the development of these complications are not yet fully understood, it has been proposed that emergence of aGVHD contributes to the development of kidney injury after HSCT. We have shown previously that aGVHD targets the kidney in a biphasic manner: at the onset, inflammatory genes are up-regulated, while when aGVHD becomes established, donor lymphocytes infiltrate the kidney. Here, we characterize renal manifestations at the onset of aGVHD. Mice receiving allogeneic bone marrow and spleen cells displayed symptoms of aGVHD and elevated serum levels of tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) within 4 days. There was concurrent kidney injury with the following characteristics: (1) elevated expression of the kidney injury biomarker, neutrophil gelatinase-associated lipocalin (NGAL), (2) accumulation of hetero-lysosomes in proximal tubule epithelial cells, and (3) reductions in alpha Klotho mRNA and protein and increased serum levels of fibroblast growth factor 23 (Fgf23), phosphate and urea. This situation resembled acute renal injury caused by bacterial lipopolysaccharide. We conclude that the onset of aGVHD is associated with kidney injury involving down-regulation of alpha Klotho, a sight that may inspire novel therapeutic approaches.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Acute graft versus host disease
- Fibroblast growth factor 23
- alpha Klotho
- Hematopoietic stem cell transplantation
- Interferon gamma
- Kidney injury
- Lysosome
- Tumor necrosis factor alpha
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Amin, Risul
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He, Rui
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Gupta, Dhanu
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Zheng, Wenyi
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Burmakin, Mikhai ...
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Mohammad, Dara K ...
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show more...
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DePierre, Joseph ...
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Sadeghi, Behnam
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Olauson, Hannes
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Wernerson, Annik ...
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El-Andaloussi, S ...
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Hassan, Moustaph ...
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Abedi-Valugerdi, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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International Im ...
- By the university
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Stockholm University
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Uppsala University
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Karolinska Institutet